Intake of tomato-enriched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons [0.03%]
番茄膳食摄入可以保护黑质多巴胺能神经元免于6-羟基多巴胺诱导的退变
Vincenzo di Matteo,Massimo Pierucci,Giuseppe Di Giovanni et al.
Vincenzo di Matteo et al.
There is extensive evidence that oxidative damage of dopamine (DA)-containing neurons in the substantia nigra pars compacta (SNc) may contribute to the pathogenesis of Parkinson's disease (PD). We evaluated the potential neuroprotective eff...
Giuseppe Di Giovanni
Giuseppe Di Giovanni
Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the unde...
Daniela Besong Agbo,Frauke Neff,Florian Seitz et al.
Daniela Besong Agbo et al.
Parkinson's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated ...
Takao Yasuhara,Isao Date
Takao Yasuhara
Parkinson's disease is characterized by the degeneration of the nigrostriatal dopaminergic neurons with the manifestation of tremor, rigidity, akinesia, and disturbances of postural reflexes. Medication using L-DOPA and surgeries including ...
K-C Sonntag,F Simunovic,R Sanchez-Pernaute
K-C Sonntag
Parkinson's disease (PD) is a neurodegenerative disorder caused by a progressive degeneration of the midbrain dopamine (DA) neurons in the substantia nigra pars compacta (SNc) that predominantly affects the ventral population projecting to ...
Oscar Arias-Carrión,Elizabeth Yamada,Nils Freundlieb et al.
Oscar Arias-Carrión et al.
The clinical motor dysfunction in Parkinson's disease is primarily the consequence of a progressive degeneration of dopaminergic neurons in the substantia nigra of the nigrostriatal pathway. The degeneration of this tract provokes a depleti...
Cannabinoid CB1 receptors are early downregulated followed by a further upregulation in the basal ganglia of mice with deletion of specific park genes [0.03%]
特定帕金森基因缺失小鼠纹状体内大麻素CB1受体早期下调而后进一步上调
Moisés García-Arencibia,Concepción García,Alexander Kurz et al.
Moisés García-Arencibia et al.
This study was designed to examine the type of changes experienced by the CB1 receptor, a key element of the cannabinoid signaling system, in the basal ganglia of different mouse mutants generated by deletion of specific genes associated wi...
Distinct effects of intranigral L-DOPA infusion in the MPTP rat model of Parkinson's disease [0.03%]
左旋多巴对梅克尔碱诱导的帕金森病大鼠黑质纹状体的影响
Angela B Reksidler,Marcelo M S Lima,Patrícia A Dombrowski et al.
Angela B Reksidler et al.
The potential neuroprotective or neurotoxic effects of 3,4-dihydroxyphenylalanine (L-DOPA) are yet to be understood. We examined the behavioral, immunohistochemical, tyrosine hydroxylase (TH) expression and neurochemical parameters after an...
Increase of secondary processes of microglial and astroglial cells after MPTP-induced degeneration in substantia nigra pars compacta of non human primates [0.03%]
非人灵长类动物黑质致密部MPTP变性后小胶质细胞和星形胶质细胞二级过程的增多
Carlos Barcia,Carmen M Ros,María A Carrillo et al.
Carlos Barcia et al.
Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated with dopaminergic cell loss. How...
Carlos Barcia,Francisco Ros,María Angeles Carrillo et al.
Carlos Barcia et al.
Inflammatory responses have been proposed as important factors in dopaminergic neuro-degeneration in Parkinsonism. Increasing evidence suggests that the alteration of the glial microenvironment induced by neuronal degeneration could be dele...