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Apoptosis inhibition in T cells triggers the expression of proinflammatory cytokines--implications for the CNS

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Stimulation of death receptors such as CD95 or TNF-R1 results in rapid onset of apoptosis. Here we show that inhibition of death receptor-induced apoptosis by the broad range caspase inhibitor ZVAD causes a switch from apoptotic to proinflammatory signaling. I... ...