ICAM1 promotes the invasion and metastasis of Epstein-Barr virus (EBV) positive nasopharyngeal carcinoma (NPC) cells by regulating the CCR7-JAK3/STAT3 axis to modulate PD-L1 expression [0.03%]
ICAM1通过调节CCR7-JAK3/STAT3轴调控PD-L1表达从而促进 Epstein-Barr病毒阳性鼻咽癌细胞的侵袭和转移
Y Liu,R Fu,W Sun et al.
Y Liu et al.
Background: In patients with locally advanced, metastatic, or recurrent nasopharyngeal carcinoma (NPC), immunotherapy, especially with programmed cell death ligand 1 (PD-L1) inhibitors, is increasingly being applied for c...
Linking form to function: a scoping review of the evolution of paranasal sinuses in mammals [0.03%]
形态与功能的关系：哺乳动物鼻旁窦演化范围性评价
L E Ebbert,N Kumar,M K Ebbert et al.
L E Ebbert et al.
Background: The evolutionary origin and function of paranasal sinuses remain unclear. We investigated their presence, distribution, and drainage orientation across mammalian orders, to better understand their evolutionary...
A R Sedaghat
A R Sedaghat
We are currently in a period of exciting advances for understanding of pathophysiology and treatment for conditions across the entire spectrum of rhinology. These discoveries have unlocked new ways of thinking and novel approaches to patien...
A R Sedaghat
A R Sedaghat
We are currently in a period of exciting advances for understanding of pathophysiology and treatment for conditions across the entire spectrum of rhinology. These discoveries have unlocked new ways of thinking and novel approaches to patien...
Nasal endoscopic indocyanine green fluorescence imaging guided surgery for recurrent nasopharyngeal carcinoma [0.03%]
鼻内镜下亚甲蓝荧光引导手术治疗复发性鼻咽癌
T Liang,J Li,X Hu et al.
T Liang et al.
Introduction: To evaluate the feasibility and diagnostic value of indocyanine green (ICG) fluorescence imaging in the surgical treatment of recurrent nasopharyngeal carcinoma (rNPC). ...
Subepithelial ALOX15+ macrophage niches orchestrate eosinophil recruitment in chronic rhinosinusitis with nasal polyps via the ALOX15-ERK-CCL13 axis [0.03%]
慢性鼻窦炎伴鼻息肉中Alox15+巨噬细胞龛通过Alox15-ERK-Ccl13轴募集嗜酸性粒细胞
Y Cui,C Liu,K Wang et al.
Y Cui et al.
Background: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by intense type 2 inflammation and high recurrence rate. The precise spatial determinants and cellular mechanisms sustaining tis...
Dupilumab in chronic rhinosinusitis without nasal polyps: randomized phase 2 trial (ORION) [0.03%]
dupilumab治疗无鼻息肉慢性鼻窦炎的随机II期试验（ORION）
S E Lee,A T Peters,P Gevaert et al.
S E Lee et al.
Background: Chronic rhinosinusitis (CRS) is often driven by type 2 inflammation and is characterized by nasal obstruction/ discharge, facial pain/pressure, and/or reduced smell, either with or without nasal polyps (CRSwNP...
Upper airway disease in Jeju Haenyeo: the aging and resilience cohort (JH-ARC) study [0.03%]
济州海女上呼吸道疾病：老龄化与韧性队列（JH-ARC）研究
S W Chang,M Kang,J Lee et al.
S W Chang et al.
Jeju Haenyeo are traditional female breath-hold divers from Jeju Island, the southernmost and largest island of the Republic of Korea, who harvest marine products without modern diving equipment (1). During diving, they are repeatedly expos...
Nasal biopsy in ANCA-associated vasculitis: a game changer or a false friend? [0.03%]
anca相关性血管炎的鼻甲活检：游戏规则改变者还是虚假朋友？
L Gazzini,I Girolami,S Niederbacher et al.
L Gazzini et al.
Ear-nose-throat (ENT) involvement is common in ANCA associated vasculitis, particularly in granulomatosis with polyangiitis (GPA) and EGPA eosinophilic granulomatosis with polyangiitis (EGPA), with sinonasal manifestations frequently repres...
Pharmacological silencing of nasal TRPV1+ nociceptors ameliorates eosinophilic infiltration but exacerbates neutrophilic infiltration in murine models of allergic rhinitis [0.03%]
药理学沉默鼻内TRPV1阳性伤害感受器可改善小鼠过敏性鼻炎模型中的嗜酸性粒细胞浸润，但会加重中性粒细胞浸润
F Ye,Y Tao,J Chen et al.
F Ye et al.
Background: The pathogenesis of allergic rhinitis (AR) involves hyperreactivity of both the immune and neural systems. While sensory nerves detect allergens and release neuropeptides that directly participate in immune re...