Subepithelial ALOX15+ macrophage niches orchestrate eosinophil recruitment in chronic rhinosinusitis with nasal polyps via the ALOX15-ERK-CCL13 axis
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Background: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by intense type 2 inflammation and high recurrence rate. The precise spatial determinants and cellular mechanisms sustaining tissue eosi... ...