The challenges and opportunities of developing small molecule inhibitors of MraY [0.03%]
开发MraY小分子抑制剂的挑战与机遇
Destinee Manning,Tzu-Yu Huang,Tomayo Berida et al.
Destinee Manning et al.
Elisabetta Groaz,Erik De Clercq,Piet Herdewijn
Elisabetta Groaz
Despite considerable progress in the development of antiviral drugs, among which anti-immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be considered real success stories, many viral infections remain without an ...
Katherine L Seley-Radtke,Joy E Thames,Charles D Waters rd
Katherine L Seley-Radtke
The current focus for many researchers has turned to the development of therapeutics that have the potential for serving as broad-spectrum inhibitors that can target numerous viruses, both within a particular family, as well as to span acro...
Improving properties of the nucleobase analogs T-705/T-1105 as potential antiviral [0.03%]
作为潜在抗病毒药物的核碱基类似物T-705/T-1105的性质改进
Xiao Jia,Benedikt Ganter,Chris Meier
Xiao Jia
In this minireview we describe our work on the improvement of the nucleobase analogs Favipiravir (T-705) und its non-fluorinated derivative T-1105 as influenza and SARS-CoV-2 active compounds. Both nucleobases were converted into nucleotide...
F Brad Johnson
F Brad Johnson
Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A la...
Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy [0.03%]
病毒G-四链体：病毒发病机制和抗病毒治疗的新前沿
Emanuela Ruggiero,Sara N Richter
Emanuela Ruggiero
Viruses are the most abundant organisms on our planet, affecting all living beings: some of them are responsible for massive epidemics that concern health, national economies and the overall welfare of societies. Although advances in antivi...
James L Kelley
James L Kelley
This chapter discusses the agents with activity primarily against RNA viruses. The communicable diseases of the respiratory tract are probably the most common cause of symptomatic human infections. The viruses that are causative agents for ...