首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

Annual reports in medicinal chemistry. 2020:54:3-44. doi: 10.1016/bs.armc.2020.06.004 Q30.02024

Fundamentals of G-quadruplex biology

G-四链体生物学基础 翻译改进

F Brad Johnson  1

作者单位 +展开

作者单位

  • 1 Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
  • DOI: 10.1016/bs.armc.2020.06.004 PMID: 32836507

    摘要 Ai翻译

    Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes from transcription and chromatin structure, mRNA processing, protein translation, DNA replication and genome stability, and telomere and mitochondrial function. Nonetheless, it must be acknowledged that some of this evidence is tentative, which is not surprising given the technical challenges associated with demonstrating G4s in biology. Here I provide an overview of evidence for G4 biology, focusing particularly on the many potential pitfalls that can be encountered in its investigation, and briefly discuss some of broader biological processes that may be impacted by G4s including cancer.

    Keywords: Antibody; Chromatin; G-quadruplex; Mitochondria; Recombination; Telomere; Transcription; Translation.

    Keywords:G-quadruplex biology

    关键词:G-四链体生物学

    Copyright © Annual reports in medicinal chemistry. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Annual reports in medicinal chemistry

    缩写:ANNU REP MED CHEM

    ISSN:0065-7743

    e-ISSN:1557-8437

    IF/分区:0.0/Q3

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Fundamentals of G-quadruplex biology