The TOM Complex in the Outer Membrane of Mitochondria: A Supramolecular Assembly for Protein Import [0.03%]
线粒体外膜中的TOM复合物：蛋白质导入的超分子装配体
Stephan Nussberger,Robin Ghosh,Shuo Wang
Stephan Nussberger
Currently, there is no comprehensive physical model explaining how unfolded polypeptide chains with diverse characteristics are transported into the mitochondria. On a molecular scale, the kinetics of how transit polypeptides approach, are ...
Conformational Dynamics and Allostery in the cAMP-Protein Kinase A Signalosome [0.03%]
环磷酸腺苷-蛋白激酶A信号体的构象动力学与别构效应
Varun Venkatakrishnan,Ganesh S Anand
Varun Venkatakrishnan
Protein kinase A (PKA) is a master kinase that controls numerous cellular processes via phosphorylation. PKA, or cAMP-dependent protein kinase, is regulated by the second messenger 3'5' cyclic adenosine monophosphate (cAMP) generated in res...
Zhangfei Shen,Chen Wang,Tian-Min Fu
Zhangfei Shen
Inflammasomes are large cytosolic protein complexes that detect and respond to pathogenic and endogenous danger signals, triggering critical innate immune defenses. This chapter outlines the structural and mechanistic features of canonical ...
Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions [0.03%]
细胞连接中有序多组分组装的结构见解
Oliver James Harrison,Priyanka Mathews,Julia Brasch
Oliver James Harrison
Cell junctions are essential structures of metazoan tissues that maintain cohesion and integrity and permit coordinated tissue rearrangements in development. Vertebrate junctions include stable structures, like adherens junctions, desmosome...
Introduction [0.03%]
导论
Stephen J Benkovic
Stephen J Benkovic
Owing to a lengthy career, I occupied a ringside seat to watch the evolution of our understanding of enzymatic catalysis. The field has progressed from primitive bioorganic models of enzyme active sites, which guided physical organic-based ...
Retraction Note to: Transformative Therapies for Wound Care: Insights into Tissue Engineering and Regenerative Medicine [0.03%]
撤稿说明：伤口护理的变革性疗法：组织工程和再生医学的启示
Mrunal Damle,Vaishali Gaikwad,Meghnad G Joshi
Mrunal Damle
Synthesis, Characterisation, and Evaluation of the Biological Activities of Medicinal Plants-Based Gold Nanoparticles [0.03%]
基于药用植物的金纳米颗粒的合成、表征及生物活性评价
Felicia Murunwa Nemaguvhuni,Afsatou Ndama Traore,Mapula Razwinani et al.
Felicia Murunwa Nemaguvhuni et al.
Gold nanoparticles (AuNPs) were synthesized using extracts from Spirostachys Africana. The AuNPs were characterised using Ultraviolet-Visible spectrophotometry (UV-Vis), X-ray diffraction (XRD), Dynamic light scattering (DLS), Transmission ...
The Role of Lactic Acid Bacteria in Colon Cancer Mitigation: Insights into Mechanisms of Action [0.03%]
乳酸菌在结肠癌防治中的作用及功效机制初探
Mduduzi P Mokoena,Paul K Chelule,Ivy Rukasha et al.
Mduduzi P Mokoena et al.
Lactic acid bacteria (LAB) have garnered significant attention for their potential role in mitigating cancer through various mechanisms of action, such as immunoregulation. The LAB, primarily from the genera Lactobacillus and Bifidobacteriu...
Levanco K Asia,Tshiamo W Sebigi,Du Toit Loots et al.
Levanco K Asia et al.
HIV remains a global health challenge, affecting millions of individuals worldwide. While combination antiretroviral therapy (cART) significantly reduces viral loads to undetectable levels, it does not eradicate the virus completely, and a ...
Neuroinflammatory and Neurodegenerative Roles of HIV-1 Tat: A Review of Recent Evidence [0.03%]
HIV-1蛋白Tat的神经炎症及神经退行性疾病作用：近期证据回顾
Monray E Williams,Tshengedzeni Muvenda,Vhuthuhawe Mugwena et al.
Monray E Williams et al.
HIV-1 remains a major global health concern, exerting detrimental effects not only on the immune system but also on the central nervous system (CNS). Soon after HIV-1 infection, the virus can breach the blood-brain barrier (BBB), initiating...