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Conformational Dynamics and Allostery in the cAMP-Protein Kinase A Signalosome

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Protein kinase A (PKA) is a master kinase that controls numerous cellular processes via phosphorylation. PKA, or cAMP-dependent protein kinase, is regulated by the second messenger 3'5' cyclic adenosine monophosphate (cAMP) generated in response to upstream ... ...