Yasuki Miyagawa,Kei Miyamoto
Yasuki Miyagawa
Embryogenesis begins with fertilization, resulting in a totipotent zygote that undergoes a complex series of cellular and molecular events toward the development of a complete organism. During this period, critical events such as zygotic ge...
Haruka Oda,Nao Yonezawa,Kazuo Yamagata
Haruka Oda
Time is an important physical factor controlling all biological phenomena. Within the short period from fertilization to preimplantation, various events occur in a timely manner. A rapid replication of the genome and extensive epigenetic re...
Takashi Ishiuchi
Takashi Ishiuchi
Early mammalian development entails one of the most extensive and physiologically relevant episodes of epigenomic reprogramming. Following fertilization, two highly specialized gametic epigenomes are reset to establish a totipotent zygotic ...
Oocyte Kinetochores at the Nexus of Meiotic Drive and Segregation Fidelity [0.03%]
卵母细胞动力蛋白主效子在染色体分离保真度和动粒驱动的交叉点上
Preethi Kunchala,Takashi Akera
Preethi Kunchala
Faithful chromosome segregation in oocytes relies on the precise coordination of core centromeric chromatin, dynamic kinetochore assembly, and spindle interactions. In meiosis I, sister kinetochores are mono-oriented toward the same spindle...
Asymmetric Chromosome Establishment and Segregation During Germline Stem Cell Division [0.03%]
生殖干细胞分裂过程中染色体的不对称建立与分离
Yijun Liao,Xin Chen
Yijun Liao
In metazoans, gametogenesis produces the only cell type capable of transmitting both genetic and epigenetic information to offspring. This process represents one of the most extensive cellular differentiation programs, often originating fro...
Non-random Sister Chromatid Segregation Mediated by Ribosomal DNA in Drosophila Male Germline Stem Cells [0.03%]
果蝇雄性 germline stem cells 中由核糖体DNA介导的非随机姐妹染色单体分离
George J Watase
George J Watase
Germline stem cells (GSCs) in the testis are responsible for producing sperm. In Drosophila, GSCs almost always divide asymmetrically, resulting in one self-renewing GSC and one differentiating cell called the gonialblast (GB), which then d...
Centriole Duplication, Maturation, and Transformation During Mammalian Spermatogenesis [0.03%]
哺乳动物精子发生过程中中心粒的复制、成熟及转变
Morié Ishida,Hiroki Shibuya
Morié Ishida
Spermatogenesis is the process by which spermatozoa are produced from spermatogonia through two rounds of meiotic divisions to form spermatocytes, followed by a series of transformations to form spermatids. Unlike what occurs in oogenesis, ...
Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells [0.03%]
哺乳动物生殖细胞中由减数分裂特异性黏连素决定的染色体结构
Kei-Ichiro Ishiguro,Yasuhiro Fujiwara
Kei-Ichiro Ishiguro
Sister chromatid cohesion, established by the cohesin complex, is indispensable for accurate chromosome segregation in both mitosis and meiosis. Whereas mitosis relies predominantly on the canonical cohesin complex composed of SMC1α, SMC3,...
Yukiko Imai
Yukiko Imai
Teleosts (teleost fishes), comprising over 30,000 species-roughly half of all living vertebrates-exhibit remarkably diverse patterns of meiotic recombination. Recent genome-wide analyses as well as cytological studies provide new insights b...
Chromatin-Based Control of Mammalian Sex Determination: Integrating Epigenetic and Metabolic Mechanisms [0.03%]
染色质调控哺乳动物性别决定：整合表观遗传和代谢机制
Naoki Okashita,Makoto Tachibana
Naoki Okashita
Recent studies have demonstrated that mammalian sex determination is governed not only by trans-acting transcription factors but also by cis-acting chromatin modifications. This review summarizes recent advances in understanding how histone...