Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach [0.03%]
通过多组分方法快速合成海葱胺和水石竹烷核心骨架
Nicholas P Massaro,Joshua G Pierce
Nicholas P Massaro
A rapid synthesis of the core structures of crinane and haemanthamine has been developed, enabled by a multicomponent approach. This work constitutes a formal synthesis of crinane and sets the stage for access to both families of natural pr...
Towards a streamlined synthesis of peptides containing α,β-dehydroamino acids [0.03%]
含α,β-脱氢氨基酸肽的简洁合成法
Diego A Moyá,Michael A Lee,Joseph C Chanthakhoun et al.
Diego A Moyá et al.
Investigation of a strategy to streamline the synthesis of peptides containing α,β-dehydroamino acids (ΔAAs) is reported. The key step involves generating the alkene moiety via elimination of a suitable precursor after it has been insert...
De Novo S ynthesis of an l-Lemonose Thioglycoside Donor from d-Threonine [0.03%]
以d-苏氨酸为原料的l-柠檬糖硫苷配体的从头合成
Eric D Huseman,Steven D Townsend
Eric D Huseman
A short de novo synthesis of an l-lemonose thioglycoside is described starting from d-threonine. The synthesis leverages a Dieckmann condensation and Stork-Danheiser transposition to arrive at a key vinylogous ester intermediate on gram sca...
Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III [0.03%]
环[b]氧杂螺[3.2.1]辛烷片段的合成研究 Rhodesinosin III
Caroline G Webster,Hyeri Park,Amanda F Ennis et al.
Caroline G Webster et al.
Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explore...
A cascade reaction of cinnamyl azides with vinyl sulfones directly generates dihydro-pyrrolo-pyrazole heterocycles [0.03%]
茋基叠氮化物与烯基磺酮的级联反应直接生成二氢吡咯并吡唑杂环化合物
Angela S Carlson,Alexandru M Petre,Joseph J Topczewski
Angela S Carlson
This report describes the direct synthesis of dihydro-pyrrolo-pyrazole heterocycles from allylic azides and methyl vinyl sulfone. The product results from a complex cascade reaction that is operationally straightforward, with aromatization ...
Ultrasound assisted one-pot synthesis of benzo-fused indole-4, 9-dinones from 1,4-naphthoquinone and α-aminoacetals [0.03%]
声波促进的一锅法合成菲并吲哚-4,9-二酮类化合物
Quang H Luu,Jorge D Guerra,Cecilio M Castañeda et al.
Quang H Luu et al.
A one-pot synthesis of benzo[f]indole-4,9-diones from 1,4-naphthoquinone with α-aminoacetals has been developed. This method provides a straightforward synthesis of benzo[f]indole-4,9-diones via intramolecular nucleophilic attack of aminoq...
Matthew J Mitcheltree,Zef A Konst,Seth B Herzon
Matthew J Mitcheltree
A practical and efficient method for the perfluorobutanesulfonyl azide-mediated one-carbon ring contraction of cyclic enoxysilanes is described. High-yielding procedures for the elaboration of the resulting N-acyl sulfonamide products are r...
Jung-Ho Son,Amy Cheung,Jie S Zhu et al.
Jung-Ho Son et al.
A Davis-Beirut reaction inspired nitroso Diels-Alder protocol is reported. The starting material for the procedure is a nitrophenyl moiety with the para position appropriately substituted with a 2°-amine (see 5) or 2°-alcohol (see 6). Dep...
A concise Diels-Alder strategy leading to congeners of the ABC ring system of the marine alkaloid 'upenamide [0.03%]
一种简洁的狄尔斯-阿尔德策略得到海洋碱性化合物'upenamide'ABC环体系类似物的方法
Marta E Wenzler,Bruce J Melancon,Gary A Sulikowski
Marta E Wenzler
A second-generation approach to the BC spirocycle of 'upenamide is reported. Central to the synthesis is an endo selective Diels-Alder reaction between 1-(t-butyldimethylsiloxy)-1,3-butadiene and bromomaleic anhydride followed by a radical ...
Chalcone-analogue fluorescent prfobes for saccharides signaling using the boronic acid group [0.03%]
用于糖标示的茋类似荧光探针的硼酸基团
Nicolas DiCesare,Joseph R Lakowicz
Nicolas DiCesare
Two new fluorescent probes based on 1,3-diphenylprop-2-en-1-one and on 1,5-diphenylpenta-2,4-dien-1-one structures are presented. Both probes posses one electron-donating dimethylamino group and one boronic acid group (electron-withdrawing ...