A concise Diels-Alder strategy leading to congeners of the ABC ring system of the marine alkaloid 'upenamide
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A second-generation approach to the BC spirocycle of 'upenamide is reported. Central to the synthesis is an endo selective Diels-Alder reaction between 1-(t-butyldimethylsiloxy)-1,3-butadiene and bromomaleic anhydride followed by a radical mediated allylation ... ...
