Halogenated Pyridine Derivatives from Cycloaddition / Cycloreversion of Oxazinone and Haloalkyne Precursors [0.03%]
通过氧化偶氮酮和 haloalkynes 前体的环加成/环逆转反应制备含卤素吡啶衍生物
Elizabeth A Davis,Megan S Hammett,Jonathan R Scheerer
Elizabeth A Davis
This study explores the merged cycloaddition/cycloreversion of 1,4-oxazinone substrates with haloalkyne 2π reaction components. Haloalkynes proved generally competent in the Diels-Alder operation and exerted a small influence on the regios...
Sayan Roy,Divya Garg,Christopher Uyeda
Sayan Roy
A nickel catalyst promotes the reductive annulation of alkenes using 1,3-dihalopropanes to provide substituted cyclopentanes. Mechanistic studies indicate that activation of the dihaloalkane occurs by a halogen-atom abstraction mechanism to...
Regioretention Probes Distinguish Ring Scission Mechanisms in Nitrogen Insertion Reactions [0.03%]
氮插入反应中的环裂解机理区分：区域保留探测器研究
Yahia Ali,Liao Chen,Mark D Levin
Yahia Ali
Atom insertion reactions into ring systems may occur via one of two pathways, proceeding either through initial cyclization to form a 3-membered ring intermediate followed by cleavage of the ring-fusion bond, or through initial ring-scissio...
Formation of Vicinal Secondary and All-Carbon Quaternary Stereocenters in Enantioenriched Diazenes via Branched-Selective Pd-Catalyzed Allylic Alkylation [0.03%]
钯催化支链选择性烯丙基化反应构建高光学纯度亚胺𬭩盐中的 vic-仲手性中心和全碳季碳手性中心
Adam J Zoll,Chloe S Cerione,Scott C Virgil et al.
Adam J Zoll et al.
The synthesis of enantioenriched alkyl diazenes with vicinal secondary and all carbon quaternary stereocenters via palladium-catalyzed allylic alkylation is reported. Diazenes were formed in high diastereoselectivity and modest enantioselec...
Iron-Catalyzed Glycal cis-Aminoacyloxylation for 2-Amino Saccharide Synthesis [0.03%]
铁催化甘基顺式氨基酰化反应用于合成2-氨基糖
Le Yin,Dakang Zhang,Zixiang Jiang et al.
Le Yin et al.
We report here a new catalytic and exclusively 1,2-cis-selective glycal aminoacyloxylation method for 2-amino saccharide synthesis. This iron-catalyzed glycosylation is effective for a wide variety of glycosyl donors with consistently high ...
On the Unexpected Formation of [2.2.1]- and [2.1.1]Homotriblattanes [0.03%]
unexpectedly形成的[2.2.1]和[2.1.1]homotriblattane
Adrian E Samkian,Hanh T Nguyen,Christopher D Vanderwal et al.
Adrian E Samkian et al.
A new class of polycyclic caged compounds, the [2.n.1]homotriblattanes, is described herein. These scaffolds are accessed through a concise, three-step sequence featuring an unexpected radical cyclization of α-bromocyclopropyl ketones. The...
Weihao Ma,J Tyler McBride,Robert S Phillips
Weihao Ma
Nitroarenes are critically important in medicinal chemistry, material science, and the chemical industry. In this paper, we introduce a new strategy for the electrophilic nitration of deactivated aromatic compounds, utilizing lithium nitrat...
On the gold(I)-catalyzed enantioselective addition of indole to diphenylallene via anion-binding catalysis [0.03%]
基于阴离子结合催化的金(I)催化吲哚加成到二苯基烯亚甲基的不对称反应研究
Banruo Huang,Binh Khanh Mai,Ulrike Warzok et al.
Banruo Huang et al.
Neutral dual hydrogen bond donors (HBDs) are effective catalysts that enhance the electrophilicity of substrates or the Lewis/Brønsted acidity of reagents through an anion-binding mechanism. Despite their success in various enantioselectiv...
An attempted oxidative coupling approach to the scholarinine A framework [0.03%]
一种用于构建scholarinine A骨架的偶联反应尝试
Kerry E Jones,Fernando Martínez Lara,Blane P Zavesky et al.
Kerry E Jones et al.
In this manuscript, an oxidative carbon-carbon bond forming reaction to construct the framework of alkaloids such as scholarinine A is explored using a constrained substrate. Instead of the desired carbon-carbon bond formation between an in...
A Mild and Chemoselective Photoredox-Catalyzed Reduction of Aromatic Ketones [0.03%]
一种温和且化学选择性的光氧化还原催化芳香酮的还原反应
Chris Boeke,Aerin Mellott,Gahan Lahiri et al.
Chris Boeke et al.
A mild, chemoselective reduction of aromatic ketones was discovered and investigated. The combination of photoredox and Lewis acid catalysis with an organic hydrogen source reduced aromatic ketones in good to high yield. Optimization found ...