Synthesis of N,N-Diethylbenzamides via a Non-Classical Mitsunobu Reaction [0.03%]
非经典mitsunobu反应合成N，N-二乙基苯甲酰胺类化合物
J Mason Hoffman,Justin N Miller,Margaret E Gardner et al.
J Mason Hoffman et al.
The use of the Mitsunobu reaction for the synthesis of N,N-diethylbenzamides affords ortho-, meta-, and para-substituted benzamides, containing both electron-donating and electron-withdrawing groups. While the preparation of numerous functi...
Synthesis of 3-(1-Methyl-1 H-imidazol-2-ylthio)propanoic Acid and (E)-3-(1-Methyl-1 H-imidazol-2-ylthio)acrylic Acid [0.03%]
3-(1-甲基-1H-咪唑-2-基硫基)丙酸和(E)-3-(1-甲基-1H-咪唑-2-基硫基) acrylic acid的合成反应研究
Christopher M Hattan,Jalil Shojaie,Serrine S Lau et al.
Christopher M Hattan et al.
The syntheses of 3-(1-methyl-1H-imidazol-2-ylthio)acrylic acid and 3-(1-methyl-1H-imidazol-2-ylthio)propanoic acid, mitochondria-targeted prodrugs of the antioxidant methimazole, are described. The method of Fan et al. (Fan et al., Synthesi...
IMPROVED SYNTHESIS OF 10-(2-ALKYLAMINO-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID DERIVATIVES BEARING ACID-SENSITIVE LINKERS [0.03%]
带有酸敏感连接臂的10-[2-烷基氨基-2-氧代乙基]-1，4，7，10-四氮杂环十二烷-1，4，7-三乙酸衍生物的改进合成法
Bhumasamudram Jagadish,Tarik J Ozumerzifon,Sue A Roberts et al.
Bhumasamudram Jagadish et al.
Alkylation of the hydrobromide salts of 1,4,7-tris(methoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane and 1,4,7-tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane with appropriate α-bromoacetamides, followed by hydrolysis, provid...
Syntheses of Benzo[ b]furan-6-carbonitrile and 6-Cyanobenzo[ b]furan-2-boronic Acid Pinacol Ester [0.03%]
6-氰基苯并[b]呋喃和6-氰基-2-硼酸频那酯苯并[b]呋喃的合成
John D Williams,Xiaoyuan Ding,Son Nguyen et al.
John D Williams et al.
6-Cyanobenzo[b]furan-2-boronic acid pinacol ester (10) is a potentially useful 2-point scaffold for the construction of specific compounds or compound libraries with benzofuran cores. Using a per-iodination/de-iodination strategy coupled wi...
Adam F Tracy,Matthew P Abbott,Douglas A Klumpp
Adam F Tracy
1,2-Indandione reacts efficiently with arenes to give 2,2-diaryl-1-indanones by the hydroxyalkylation reaction. The Brønsted superacid CF3SO3H (triflic acid) is an effective catalyst for these condensation reactions. The requisite 1,2-inda...
Esterification Catalysis by Pyridinium p-Toluenesulfonate Revisited-Modification with a Lipid Chain for Improved Activities and Selectivities [0.03%]
revisit-通过添加脂链改善酯化反应的活性和选择性
Wei Wang,Huimin Liu,Shaoyi Xu et al.
Wei Wang et al.
The lipid analogues of pyridinium p-toluenesulfonate (PPTS) were examined for catalyzing the condensation of an equimolar mixture of carboxylic acids and alcohols under mild conditions without removal of water. Although PPTS is a poor catal...
Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid [0.03%]
廉价高效的溶血磷脂酸(16:0)的合成方法
James E East,Timothy L Macdonald
James E East
Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Popularity of the compound has necessitated the use of large quantities of the phospholipid for in vivo and in vitro testi...
SYNTHESIS OF SYMMETRICAL METHYLENEBIS(ALKYL HYDROGEN PHOSPHONATES) BY SELECTIVE CLEAVAGE OF METHYLENEBIS(DIALKYL PHOSPHONATES) WITH MORPHOLINE [0.03%]
甲醇胺选择性开环缩合甲ylene双(二烷基次膦酸酯)的合成
Gantla Vidyasagar Reddy,Hollie K Jacobs,Aravamudan S Gopalan et al.
Gantla Vidyasagar Reddy et al.
The preparation of partial esters of methylenebisphosphonic acids has been of recent interest due to their potential therapeutic applications. This paper describes a convenient method to prepare symmetrical methylenebis(alkyl hydrogen phosp...
Christian S Jungong,Alexei V Novikov
Christian S Jungong
A practical synthesis of resveratrol 3-O-β-D-glucuronide, suitable for preparation of large quantities, was developed using selective deacetylation of resveratrol triacetate with ammonium acetate. A simplified procedure for large scale pre...
SYNTHESIS OF N-SUBSTITUTED CARBONYLAMINO-1,2,3,6-TETRAHYDROPYRIDINES AS POTENTIAL ANTI-INFLAMMATORY AGENTS [0.03%]
N-取代羰基氨基-1，2，3，6-四氢吡啶类抗炎药物的合成研究
Mohammad A Ghaffari,Tiffany W Ardley,Madhavi Gangapuram et al.
Mohammad A Ghaffari et al.
Several N-substituted carbonyl/sulfonylamino-1,2,3,6-tetrahydropyridines (5a-i and 9a, b) were synthesized via sodium borohydride reduction of the corresponding N-substitutedimino-pyridinium ylides (4a-i and 8a, b) in absolute ethanol.