Efficient Reductions of Dimethylhydrazones using Preformed Primary Amine Boranes [0.03%]
预形成的伯胺硼烷高效还原二甲基希夫碱的研究
Christian Frabitore,Jerome Lepeule,Bradley Towey et al.
Christian Frabitore et al.
A convenient method for the reduction of N,N-dimethylhydrazones using amine borane complexes generated in situ is described. It was found that primary amine borane complexes performed exceedingly well at reducing N,N-dimethylhydrazones in a...
Design and synthesis of a novel ZB716-d6 as a stable isotopically labeled internal standard [0.03%]
新型ZB716-d6的设计与合成作为稳定的同位素标记内标
Shilong Zheng,Jiawang Liu,Borui Kang et al.
Shilong Zheng et al.
ZB716 is a synthetic, steroidal, orally active anti-estrogen agent that is under clinical development for the treatment of estrogen receptor (ER)-positive metastatic breast cancer. The stable isotope-labeled ZB716 was required for use as an...
The succinct synthesis of AT13387, a clinically relevant Hsp90 inhibitor [0.03%]
临床相关Hsp90抑制剂AT13387的简洁合成方法
Jatinder Kaur,Atul Bhardwaj,Bruce J Melancon et al.
Jatinder Kaur et al.
AT13387 is an orally bioavailable clinical candidate developed to inhibit theheat shock protein 90 (Hsp90). This article describes a modified synthetic route for the multi-gram production of AT13387 in 46% overall yield. The modified synthe...
Enantioselective synthesis of spiro[ 4H-pyran-3,3'-oxindole] derivatives catalyzed by cinchona alkaloid thioureas: Significant water effects on the enantioselectivity [0.03%]
奎宁碱硫脲催化的spiro[4H-吡喃-3,3'-吲哚]-衍生物的不对称合成：水对产物对映选择性的影响显著
Swapna Konda,Satish Jakkampudi,Hadi D Arman et al.
Swapna Konda et al.
An efficient stereoselective three-component reaction for the synthesis of functionalized spiro[4H-pyran-3,3'-oxindole] derivatives was realized through an organocatalyzed domino Knoevenagel/Michael/cyclization reaction using a cinchonidine...
Synthesis of indolo[4,3- bc]phenanthridine-6,11(2 H,12 H)-diones using the Schiff base-homophthalic anhydride cyclization reaction [0.03%]
使用席夫碱-均苯二甲酸酐环化反应合成吲哚并[4,3-bc]菲并吡喃-6,11(2H,12H)-二酮类化合物
Mohamed S A Elsayed,Matthias Zeller,Mark Cushman
Mohamed S A Elsayed
A novel indolophenanthridine ring system has been synthesized via the Schiff base-homophthalic anhydride cyclization followed by thionyl chloride-mediated dehydrogenation and intramolecular Friedel-Crafts acylation. This adds to the array o...
THE SYNTHESIS OF 13C9-15N-LABELED 3,5-DIIODOTHYRONINE AND THYROXINE [0.03%]
13C9-15N标记的三碘甲状腺原氨酸和四碘甲状腺原氨酸的合成
Sarah A Hackenmueller,Thomas S Scanlan
Sarah A Hackenmueller
Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used f...
A General Method for Nucleophilic Aromatic Substitution of Aryl Fluorides and Chlorides with Dimethylamine using Hydroxide-Assisted Decomposition of N,N-Dimethylforamide [0.03%]
一种通用方法：以氢氧化物辅助N,N-二甲基甲酰胺分解反应实现芳氟、芳氯的亲核取代二甲胺化反应
Juana Garcia,Jacob Sorrentino,Emily J Diller et al.
Juana Garcia et al.
A practical and convenient procedure for the nucleophilic aromatic substitution of aryl fluorides and chlorides with dimethylamine was developed using a hydroxide assisted, thermal decomposition of N,N-dimethylforamide. These conditions are...
Panuwat Padungros,Alexander Wei
Panuwat Padungros
Oxidation-sensitive N,N-diaryl dithiocarbamates (DTCs) are synthesized in good yields by the generation of metal amide salts from N-benzoyl precursors, followed by addition of CS2. para-Substituted diphenylamines are prepared by electrophil...
SYNTHETICALLY USEFUL INTERMEDIATES BY DIAZOSULFONE AND SULFONATE C-H INSERTION [0.03%]
偶氮磺ones和磺酸酯C-H插入合成有用的衍生物
Duminda S Liyanage,Christian S Jungong,Alexei V Novikov
Duminda S Liyanage
Intramolecular C-H insertion on diazosulfone and diazosulfonate substrates was used to prepare synthetically useful intermediates from easily available starting materials. ...
Rapid synthesis of alkoxyamine hydrochloride derivatives from alkyl bromide and N,N'- di- tert-butoxycarbonylhydroxylamine ((Boc)2NOH) [0.03%]
由溴代烷和N,N'-双特丁氧羰基羟胺制备醇胺盐酸盐类化合物的新方法
P Suresh Jayasekara,Kenneth A Jacobson
P Suresh Jayasekara
The conventional route to alkoxyamine hydrochloride derivatives is by reaction of alkyl bromides with N-hydroxyphthalimide or N-hydroxysuccinimide followed by addition of hydrazine and HCl. Transformation of an alkyl bromide to the correspo...