Synthesis of 3-(1-Methyl-1 H-imidazol-2-ylthio)propanoic Acid and (E)-3-(1-Methyl-1 H-imidazol-2-ylthio)acrylic Acid
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The syntheses of 3-(1-methyl-1H-imidazol-2-ylthio)acrylic acid and 3-(1-methyl-1H-imidazol-2-ylthio)propanoic acid, mitochondria-targeted prodrugs of the antioxidant methimazole, are described. The method of Fan et al. (Fan et al., Synthesis2006, 2286) for the... ...