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Synthetic communications. 2016;46(23):1902-1908. doi: 10.1080/00397911.2016.1232409 Q31.82024

Synthesis of indolo[4,3- bc]phenanthridine-6,11(2 H,12 H)-diones using the Schiff base-homophthalic anhydride cyclization reaction

使用席夫碱-均苯二甲酸酐环化反应合成吲哚并[4,3-bc]菲并吡喃-6,11(2H,12H)-二酮类化合物 翻译改进

Mohamed S A Elsayed  1, Matthias Zeller  2, Mark Cushman  1

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作者单位

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University and the Purdue Center for Cancer Research, West Lafayette, Indiana 47907, United States.
  • 2 Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
  • DOI: 10.1080/00397911.2016.1232409 PMID: 29056779

    摘要 Ai翻译

    A novel indolophenanthridine ring system has been synthesized via the Schiff base-homophthalic anhydride cyclization followed by thionyl chloride-mediated dehydrogenation and intramolecular Friedel-Crafts acylation. This adds to the array of heterocyclic systems that are available through the cycloaddition reaction of imines with cyclic dicarboxylic acid anhydrides. The cytotoxicities of the indolophenanthridines were investigated in human cancer cell cultures, and the results documented significant antitumor activity in a variety of human cancer cell lines. This provides a new heterocyclic scaffold for anticancer drug design.

    Keywords: Indolophenanthridine; Schiff base; anticancer; cytotoxicity; homophthalic anhydride.

    Keywords:indolo[4; 3-bc]phenanthridine; schiff base; homophthalic anhydride; cyclization reaction

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    期刊名:Synthetic communications

    缩写:SYNTHETIC COMMUN

    ISSN:0039-7911

    e-ISSN:1532-2432

    IF/分区:1.8/Q3

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    Synthesis of indolo[4,3- bc]phenanthridine-6,11(2 H,12 H)-diones using the Schiff base-homophthalic anhydride cyclization reaction