Unexpected Regiochemical Control in the Nugent-RajanBabu Reductive Epoxide Cyclization [0.03%]
出人意料的区域选择性控制在诺根-拉詹巴布还原环氧化物cyclization反应中
Nantamon Supantanapong,Scott W Niman,Christopher D Vanderwal
Nantamon Supantanapong
The Nugent-RajanBabu reductive epoxide cyclization has become a mainstay of alternative methods to accomplish classical, biomimetic, cationic polyene cyclizations. In most cases, the regiochemical control for the formation of decalins and p...
A Chlorine-Bearing Asymmetric Center as a Stereocontrol Element in a Short Formal Synthesis of Steviol [0.03%]
含氯的手性中心在短步骤 Stevens 合成中的立体选择性控制作用
Sharon E Michalak,Christopher D Vanderwal
Sharon E Michalak
Steviol is one of myriad polycyclic terpenoids bearing oxygenation on the axially disposed C19 carbon. The presence of this C19 alcohol renders the C4 quaternary carbon stereogenic, issuing a challenge for stereoselective synthesis. Here we...
Joseph Chen,Darrian Chao,Uyen Phuong Tran et al.
Joseph Chen et al.
Hyperpolarized 13C magnetic resonance spectroscopy can provide unique insights into metabolic activity in vivo. Despite the advantages of this technology, certain metabolic pathways such as the tricarboxylic acid (TCA) cycle are more challe...
Versatile Synthesis of 6-Alkyl and Aryl Substituted Pyridoxal Derivatives [0.03%]
6-烷基和芳基取代的吡哆醛衍生物的合成
Yong-Chul Kim,Kenneth A Jacobson
Yong-Chul Kim
A versatile and convenient procedure for the functional derivatization with carbon substituents at the 6-position of pyridoxal using a Grignard reaction upon a protected N-isobutoxycarbony-loxypyridoxal chloride and Heck reactions with prot...
Elizabeth A Croll,Ohyun Kwon
Elizabeth A Croll
The Mitsunobu reaction is one the most widely known reactions in the organic chemistry canon. Despite its fame, some aspects of the mechanism remain poorly understood, 55 years after its initial discovery. This short review collates the fin...
Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing [0.03%]
简化的螺环并四苯托品衍生物康平宁A的合成及吡咯到吡啶的分子编辑变换反应
Brandon S Martin,Donghui Ma,Takeru Saito et al.
Brandon S Martin et al.
Lycopodium alkaloid complanadine A, isolated by Kobayashi et al. in 2000, is a complex and unsymmetrical dimer of lycodine. Biologically, it is a novel and promising lead compound for the development of new treatment for neurodegenerative d...
Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444) [0.03%]
改进的砷代脂肪酸（As-FA 362）和砷代烃（As-HC 444）合成方法
Miguel A Chacon-Teran,Shubhra Bhattacharjee,Jeremy D Bailoo et al.
Miguel A Chacon-Teran et al.
Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes...
Kayla Eschliman,Stefan H Bossmann
Kayla Eschliman
Isothiocyanates (ICTs) are a group of molecules that can be used for many different purposes, they exhibit anticancer, antimicrobial, antibiotic, and anti-inflammatory properties. The synthesis of isothiocyanates has been a focus of many re...
Waseem A Hussain,Marvin Parasram
Waseem A Hussain
Oxidative cleavage of alkenes leading to valuable carbonyl derivatives is a fundamental transformation in synthetic chemistry. In particular, ozonolysis is the mainstream method for the oxidative cleavage of alkenes that has been widely imp...
Jake M Aquilina,Myles W Smith
Jake M Aquilina
The Myrioneuron alkaloids are a relatively small family of plant-derived alkaloids that present an intriguing array of structural intricacy and biological properties. As such, these natural products have drawn interest from the synthetic co...