Regioselective Synthesis of Methyl Enol Ethers from Cycloalkanones via O-Methylation of Kinetic Enolates [0.03%]
动力学烯醇化物的O-甲基化环烷酮衍生物甲基烯醇醚的选择性合成
Ethan S Prout,Thais G Silva,Ohyun Kwon
Ethan S Prout
Alkyl enol ethers constitute valuable synthetic intermediates owing to their high nucleophilicity stemming from their electron-rich π-systems. Despite this potential, their application in organic synthesis has remained limited, largely bec...
Celena M Josephitis,Andrew McNally
Celena M Josephitis
Piperidines are widely found in biologically active compounds, and accessing these N-heterocycles from pyridines is a commonly used strategy. However, this approach is challenging when pyridines are embedded in complex structures, such as t...
Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity [0.03%]
通过发散式MHAT反应合成 modified fusicoccanes二萜类化合物
Dylan W Snelson,Sebastian A Fernandez,Ryan A Shenvi
Dylan W Snelson
Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein-client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification ...
Isoselenocyanates: Synthesis and Their Use for Preparing Selenium-Based Heterocycles [0.03%]
异硒氰酸酯的合成及其制备含硒杂环化合物的研究
Raul Neri,Stefan H Bossmann
Raul Neri
Isoselenocyanates (ISCs) are a class of organoselenium compounds that have been recognized as potential chemotherapeutic and chemopreventative agents against cancer(s) and infectious diseases. ISC compounds are chemically analogous to their...
Synthesis of Benzo-Fused Cycloheptanones from Cyclobutanol Derivatives by a C-C Cleavage/Cross-Coupling/Enolate Arylation Sequence [0.03%]
由环丁醇衍生物合成苯并庚内酮的C-C键断裂/交叉偶联/烯醇化物芳基化串联反应研究
Gwyneth L Pudner,Selena Dessain,Eric K Wu et al.
Gwyneth L Pudner et al.
Herein, we describe a convergent method for the synthesis of benzo-fused cycloheptanones from cyclobutanol derivatives and 1,2-dihaloarene electrophiles. The inherent ring strain of the cyclobutanol coupling partner is leveraged to drive a ...
Unexpected Regiochemical Control in the Nugent-RajanBabu Reductive Epoxide Cyclization [0.03%]
出人意料的区域选择性控制在诺根-拉詹巴布还原环氧化物cyclization反应中
Nantamon Supantanapong,Scott W Niman,Christopher D Vanderwal
Nantamon Supantanapong
The Nugent-RajanBabu reductive epoxide cyclization has become a mainstay of alternative methods to accomplish classical, biomimetic, cationic polyene cyclizations. In most cases, the regiochemical control for the formation of decalins and p...
A Chlorine-Bearing Asymmetric Center as a Stereocontrol Element in a Short Formal Synthesis of Steviol [0.03%]
含氯的手性中心在短步骤 Stevens 合成中的立体选择性控制作用
Sharon E Michalak,Christopher D Vanderwal
Sharon E Michalak
Steviol is one of myriad polycyclic terpenoids bearing oxygenation on the axially disposed C19 carbon. The presence of this C19 alcohol renders the C4 quaternary carbon stereogenic, issuing a challenge for stereoselective synthesis. Here we...
Joseph Chen,Darrian Chao,Uyen Phuong Tran et al.
Joseph Chen et al.
Hyperpolarized 13C magnetic resonance spectroscopy can provide unique insights into metabolic activity in vivo. Despite the advantages of this technology, certain metabolic pathways such as the tricarboxylic acid (TCA) cycle are more challe...
Versatile Synthesis of 6-Alkyl and Aryl Substituted Pyridoxal Derivatives [0.03%]
6-烷基和芳基取代的吡哆醛衍生物的合成
Yong-Chul Kim,Kenneth A Jacobson
Yong-Chul Kim
A versatile and convenient procedure for the functional derivatization with carbon substituents at the 6-position of pyridoxal using a Grignard reaction upon a protected N-isobutoxycarbony-loxypyridoxal chloride and Heck reactions with prot...
Elizabeth A Croll,Ohyun Kwon
Elizabeth A Croll
The Mitsunobu reaction is one the most widely known reactions in the organic chemistry canon. Despite its fame, some aspects of the mechanism remain poorly understood, 55 years after its initial discovery. This short review collates the fin...