首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

Synthesis. 2024 Sep;56(18):2909-2917. doi: 10.1055/a-2335-8736 Q22.22024

Design, Synthesis, and Assessment of Tricarboxylic Acid Cycle Probes

三羧酸循环示踪剂的设计、合成与评估 翻译改进

Joseph Chen  1, Darrian Chao  2, Uyen Phuong Tran  2, Kelvin L Billingsley  1

作者单位 +展开

作者单位

  • 1 Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.
  • 2 Department of Chemistry and Biochemistry, California State University Fullerton, Fullerton, CA 92831, USA.
  • DOI: 10.1055/a-2335-8736 PMID: 39896865

    摘要 Ai翻译

    Hyperpolarized 13C magnetic resonance spectroscopy can provide unique insights into metabolic activity in vivo. Despite the advantages of this technology, certain metabolic pathways such as the tricarboxylic acid (TCA) cycle are more challenging to examine due to the limitations associated with currently available hyperpolarized 13C probes. In this report, we systematically employ computational analyses, synthetic techniques, and in vitro studies to facilitate the design of new chemical probes for the TCA cycle. This platform allows for the rapid identification of probe scaffolds that are amenable to hyperpolarized 13C experimentation. Using these results, we have developed two 13C-labeled chemical probes, [1,4-13C2]-dipropyl succinate and [1,4-13C2]-diallyl succinate, which are employed in hyperpolarized 13C metabolic studies.

    Keywords: chemical probe; esterase; esterification; hyperpolarized 13C; in vitro assays; metabolism; tricarboxylic acid cycle.

    Keywords:design of probes; tricarboxylic acid cycle

    Copyright © Synthesis. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Synthesis-stuttgart

    缩写:SYNTHESIS-STUTTGART

    ISSN:0039-7881

    e-ISSN:1437-210X

    IF/分区:2.2/Q2

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Design, Synthesis, and Assessment of Tricarboxylic Acid Cycle Probes