[Substrate Behavior of Dissimilar Cy5-Deoxypyrimidine Nucleotides in PCR with DNA Templates of Different GC Compositions] [0.03%]
[不同GC含量DNA模板下相似Cy5-脱氧嘧啶核苷酸底物在PCR中的行为]
P M Monakova,V E Shershov,V E Kuznetsova et al.
P M Monakova et al.
The substrate properties of six pairs of fluorescently labeled deoxyuridine and deoxycytidine triphosphates (Cy5-dUTPs and Cy5-dCTPs) in PCR with Taq polymerase were compared. In each pair, the modified dU and dC contained identical fluores...
[Substrate Efficiency of Cy5-Modified Derivatives of Deoxyuridine and Deoxycytidine in the Rolling Circle Amplification] [0.03%]
[5-羧基四甲基罗丹明修饰的脱氧核糖核酸碱基衍生物在滚环放大反应中的底物效率]
P A Chirkova,S A Surzhikov,V E Kuznetsova et al.
P A Chirkova et al.
The kinetics of amplification and the features of individual and simultaneous incorporation of modified deoxynucleoside triphosphates in DNA during rolling circle amplification (RCA) have been studied. This study was carried out for six pai...
[NOS1AP Gene Polymorphism and Body Fat in Patients with Schizophrenia: A Search for Associations] [0.03%]
[NOS1AP基因多态性与精神分裂症患者体脂的关系研究]
V V Tiguntsev,I A Mednova,D A Petkun et al.
V V Tiguntsev et al.
Long-term pharmacotherapy in patients with schizophrenia can provoke antipsychotic-induced obesity. This side effect does not always meet the criteria for metabolic syndrome (MS), primarily central obesity. However, this significantly reduc...
[Omics Study of Ovarian Malignancies: From Urine Metabolomic Profile to Minimally Invasive MicroRNA Markers] [0.03%]
[卵巢恶性肿瘤的组学研究：从尿代谢组谱到微创microRNA标志物]
D S Kutilin,O N Guskova,F E Filippov et al.
D S Kutilin et al.
A search for efficient biomarkers of ovarian cancer is one of the current trends in gynecologic oncology. Metabolic profiling by ultra high-performance liquid chromatography and mass spectrometry (UHPLC-MS) yields information about the tota...
T S Usenko
T S Usenko
Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by progressive motor impairment due to the death of dopaminergic neurons in the substantia nigra (SN) of the brain. PD affects more than 1% ...
E A Yurchenko,E A Chingizova,D L Aminin et al.
E A Yurchenko et al.
Studies of antibacterial secondary metabolites of marine micromycete fungi as an element of a modern strategy for the search for new antibiotics are considered. More than half of the drugs currently used in practice have been isolated from ...
[PSGL-1: A Universal Selectin Ligand or a Signaling Molecule? (Review of the Literature)] [0.03%]
PSGL-1：一种通用的粘附分子还是信号转导分子？
N V Korotkova,R E Kalinin,I A Suchkov et al.
N V Korotkova et al.
Interactions of intercellular adhesion molecules of the selectin family with glycoconjugates of cell membranes mediate the initial stage of the adhesion cascade, which recruits leukocytes circulating in the bloodstream to sites of infection...
[De Novo Gene Birth] [0.03%]
从头基因诞生
E O Aristova,I A Volkhin,A A Denisova et al.
E O Aristova et al.
According to classic ideas, new genes emerge from old genes by duplication or horizontal transfer. Analyses of a large number of genomes in recent decades have shown that some genes have no visible homologs and have presumably emerged de no...
A A Fando,A A Ilyichev,V R Litvinova et al.
A A Fando et al.
The COVID-19 pandemic has triggered the development of new directions in vaccine development, among which DNA- and mRNA-based technologies are particularly noteworthy. The platform based on DNA vaccines is developing particularly intensivel...
[Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA] [0.03%]
RBM-B基序的点突变V546E和D547H不影响PrimPol与RPA和DNA的结合
A A Manukyan,A V Makarova,E O Boldinova
A A Manukyan
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication fork stalling at sites of DNA damage. PrimPol has DNA primase activity and synthesizes DNA primers that are used by proce...