[microRNA in the Realization of Molecular Mechanisms of Lymphocyte Development and Their Malignant Transformation] [0.03%]
微小核糖核酸在淋巴细胞发育及其恶性转化分子机制中的作用
Yu A Veryaskina,S E Titov,I B Kovynev et al.
Yu A Veryaskina et al.
The immune system consists of a diverse range of cell types, each performing its specific function. T-lymphocytes, B-lymphocytes, and NK (natural killer) cells provide protection against infections and tumors and participate in the regulati...
[Glial Progenitor Cell Therapy Improves Mitochondrial Function in the Hippocampus of 5xFAD Mice, but Does Not Restore the Multiscale Structure of Behavioral Stress Response] [0.03%]
少突胶质前体细胞移植改善5XFAD小鼠海马区线粒体功能但不能恢复行为压力反应的多尺度结构
A I Andreev,M E Neganova,Yu R Aleksandrova et al.
A I Andreev et al.
Cell therapy is increasingly used to treat a variety of medical conditions, including cancer, immune system disorders, and neurodegeneration. Stem cells secrete growth factors, signaling molecules, and extracellular vesicles, that can be us...
[Organ-Specific Changes in the Expression of Inflammatory Response and Antioxidant Defense Genes in the Late Period after Hemorrhagic Shock] [0.03%]
出血性休克晚期炎症反应和抗氧化防御相关基因表达的器官异质性研究
N V Andrianova,K N Lapin,A A Brezgunova et al.
N V Andrianova et al.
Hemorrhagic shock (HS) is a life-threatening condition that leads to multiple organ failure due to centralization of blood flow and impaired blood clotting. In this study, we investigated the acute and delayed effects of HS on the brain, ki...
[GLUT8- and AMPK-Dependent Autophagy Signaling in the Mechanism of the Neuroprotective Action of Trehalose] [0.03%]
糖胺聚糖GLUT8-和AMPK-依赖的自噬信号在海藻糖神经保护作用机制中的作用
A B Pupyshev,M A Tikhonova
A B Pupyshev
Trehalose disaccharide has a stable neuroprotective effect used in inhibiting experimental neurodegeneration. However, the mechanism of its action on brain neurons remains largely unclear. In hepatocytes, the main target of trehalose is the...
[Biochip for Determination of 92 Human Y-Chromosome Haplogroups by SNP Markers and Frequency Distribution of These Haplogroups in Slavic Population of European Russia] [0.03%]
[用于检测人类Y染色体92个单倍群的SNP芯片及其在欧洲俄罗斯斯拉夫人群中的频率分布]
I D Ivanovsky,S A Polyakov,M A Filippova et al.
I D Ivanovsky et al.
A method utilizing hydrogel biological microchips was developed to genotype markers of human Y-chromosome haplogroups. With the method, 14 core haplogroups and their 78 subclades were determined, including (subclade markers are in parenthes...
[The Level of Methylation in the Promoter Regions of DNA Repair Genes in Chronically Exposed People] [0.03%]
长期暴露人群DNA修复基因启动区的甲基化水平研究
A V Korechenkova,E A Blinova,A V Akleyev
A V Korechenkova
Nowadays, against the backdrop of a global increase in cancer incidence, the search for prognostic markers to assess individual risks is particularly relevant. Early identification of altered DNA methylation patterns may serve as a reliable...
[Toxin-Antitoxin Systems: Formation of Genetic Networks of Human Microbiome Bacteria and Prospects for Application] [0.03%]
毒抗系统：人类微生物菌群细菌基因网络的形成和应用前景
N I Akimova,M G Alekseeva,O B Bekker et al.
N I Akimova et al.
Toxin-antitoxin systems are modules consisting of genes that encode a stable toxin and a labile antitoxin. These systems are found in the genomes of most bacteria and archaea species. At present, eight types of toxin-antitoxin systems are d...
[Immunoglobulin-Like Domains Are the Key to Understanding Amyloid Aggregation] [0.03%]
免疫球蛋白功能区是解开淀粉样蛋白聚集之谜的关键
L G Bobyleva,I M Vikhlyantsev,A G Bobylev
L G Bobyleva
Modern concepts of the mechanisms of protein aggregation with an emphasis on immunoglobulin-like domains (Ig domains) as a structural platform predisposed to the formation of aggregates with amyloid properties are presented in this review. ...
I S Litvinova,A E Zubkova,D V Yudkin
I S Litvinova
Organ transplantation is a treatment method for various organ failures and other severe pathologies, applied in critical cases to save a patient's life. However, there is a severe shortage of donor organs world-wide, resulting in hundreds o...
I I Abdrakhmanova,K V Kitaeva,A V Gorodilova et al.
I I Abdrakhmanova et al.
Brain malignancies, such as glioblastoma, remain one of the most aggressive and difficult-to-treat cancers because of their heterogeneity, invasive growth, and resistance to conventional therapy. Significant recent progress in the treatment...