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P M Monakova,V E Shershov,S A Surzhikov et al.
P M Monakova et al.
In PCR with Taq polymerase on the Staphylococcus aureus genomic DNA template, the substrate properties of eight fluorescently labeled deoxyuridine and deoxycytidine triphosphates (Cy5-dUTP and Cy5- dCTP), which are dU-dC pairs with similar ...
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基于实时定量PCR数据的市售试剂盒和实验室 protocol提取人粪便DNA方法比较评价统计分析
A S Kurnosov,N N Linde,P A Molodtsova et al.
A S Kurnosov et al.
The emergence of new data on the association between the composition of the intestinal microbiota and various human diseases has generated increasing interest in microbiome research. In this context, selection of the DNA extraction method r...
Comparative Study
Molekuliarnaia biologiia. 2025 Nov-Dec;59(6):1002-1021. DOI:10.7868/S3034555325060104 2025
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A V Snezhkina,M S Fedorova,V S Pavlov et al.
A V Snezhkina et al.
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that originate in the parasympathetic paraganglia of the head and neck. The diagnosis of these tumors is challenging, and the therapeutic options are limited. The study of...
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V A Sarkisova,S Sh Karshieva,A A Makarova et al.
V A Sarkisova et al.
Ovarian cancer remains one of the most lethal malignancies with a five-year survival rate around 20% at III-IV stages, which determines the urgent need to develop new therapeutic approaches. Newcastle disease virus (NDV) has demonstrated co...
[The Role of NOX2-Mediated Oxidative Stress in Initiation of Acute Amyloid Toxicity] [0.03%]
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A A Osypov,K A Mukhina,A D Lyubanskaya et al.
A A Osypov et al.
Although the role of NADPH oxidase 2 (NOX2) in the development of Alzheimer's disease (AD) is widely recognized, its contribution to the initial stages of amyloid-induced pathology remains unclear. Intraventricular administration of β-amyl...
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组蛋白赖氨酸甲基转移酶G9a抑制剂对果蝇寿命和放射抵抗性的影响
N S Timusheva,M V Shaposhnikov,E N Proshkina et al.
N S Timusheva et al.
Histone lysine methyltransferase G9a is an important regulator of transcription of various genes and cell processes, but its role in determining aging and radioresistance is still poorly understood. The selective G9a inhibitor UNC0646 was t...
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N Zernov,D Melenteva,E Popugaeva
N Zernov
Current Alzheimer's disease (AD) therapies offer only symptomatic relief and fail to halt disease progression, underscoring the urgent need for novel therapeutic strategies. We have previously shown that selective positive allosteric modula...
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A E Gareeva et al.
Sertraline, a selective serotonin reuptake inhibitor, is widely used as a first-line drug for anxiety and depressive disorders. The clinical efficacy and adverse reactions observed with antidepressants are closely related to the concentrati...
E V Dudkina,A I Nadyrova,S A Luginskaya et al.
E V Dudkina et al.
The epidermal growth factor receptor (EGFR) is among the research subjects of most interest and remains genuinely attractive due to its key role in regulating the main conserved signaling pathways responsible for cell growth, survival, and ...
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E V Glazunova,A S Kurnosov,P A Molodtsova et al.
E V Glazunova et al.
Colorectal cancer remains one of the leading causes of cancer-related mortality, highlighting the importance of optimizing approaches for its early diagnosis and therapy. One promising area in this field is the investigation of the role of ...