[Recombinase-Based Engineering of Plant Genomes in the Era of Genome Editing] [0.03%]
genome编辑时代基于重组酶的植物基因组工程改造]
S M Rozov,E V Deineko
S M Rozov
The rapidly evolving CRISPR/Cas-based genome editing technologies, which have dominated nearly all areas of molecular biology over the past decade, still face several unresolved challenges. One of the major limitations of current genome edi...
[Prediction of New Nε-Acetylation Sites in the Human Proteome Based on Molecular Multilevel Neighborhoods of Atom Descriptors] [0.03%]
[基于原子描述符分子多级邻域的人类蛋白质组中新N ε-乙酰化位点的预测]
N V Lebedev,D A Filimonov,V V Poroikov et al.
N V Lebedev et al.
The Nε-acetylation of lysine residues is one of the most common processes of post-translational protein modification. As a result of the reaction between the ε-amino group of the side chain of Lys and the activated acetyl, an amide bond i...
[GeneLens: A Python Package Implementing Monte Carlo Machine Learning and Network Analysis Methods for Biomarker Discovery and Gene Functional Annotation] [0.03%]
[GeneLens：一种用于生物标志物发现和基因功能注释的Python包，实现蒙特卡洛机器学习和网络分析方法]
G J Osmak,M V Pisklova
G J Osmak
We present GeneLens, a Python package for comprehensive analysis of differentially expressed genes and biomarker discovery. The package consists of two core modules, FSelector for biomarker identification by utilizing Monte Carlo simulation...
[Substrate Specificity of E. coli Purine Nucleoside Phosphorylase in Phosphorolysis of Purine Ribonucleosides Containing a Cyclic Terpene Fragment] [0.03%]
[E.coli嘌呤核糖核苷磷酸酶对含环萜烯片段的嘌呤核糖核苷的磷解反应底物特异性研究]
A A Kozlova,V E Oslovsky,M A Varga et al.
A A Kozlova et al.
-Escherichia coli purine nucleoside phosphorylase (PNP) is used as a model enzyme to investigate metabolism and stability of biologically active nucleosides in the cell. The substrate specificity of E. coli PNP was studied in the reactions ...
[Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer] [0.03%]
微RNA的协调表达和甲基化：在乳腺癌中常见生物学进程和信号通路中的作用
E A Filippova,I V Pronina,V I Loginov et al.
E A Filippova et al.
Breast cancer remains one of the leading causes of cancer mortality among women, and the study of epigenetic mechanisms is an important task of molecular oncology in breast cancer. In this study, we analyzed the expression levels of eight m...
[Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan] [0.03%]
[(+)-乌斯酸氨异噻唑衍生物有效抑制TDP1并使肿瘤细胞对拓扑替康的作用敏感]
A A Chepanova,A L Zakharenko,N S Dyrkheeva et al.
A A Chepanova et al.
The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) removes various adducts from the 3'-end of DNA, including those induced by anticancer chemotherapeutics and is therefore considered an important therapeutic target. Previously, we...
[Spatial Organization of Chromatin of ZEB1 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells] [0.03%]
胰腺导管腺癌细胞中ZEB1基因启动子区域染色体构象分析
M V Zinovyeva,L G Nikolaev
M V Zinovyeva
Pancreatic Ductal AdenoCarcinoma (PDAC) is one of the most therapy-resistant tumors. Cultured cells originating from different stages of PDAC development are characterized by different levels of expression of a number of transcription facto...
[A Localized GTEx Database and Its Potential Applications in Biomedical Research] [0.03%]
[一个本地化的GTEx数据库及其在生物医学研究中的潜在应用]
G A Churakov,M D Belyakov,T S Sall et al.
G A Churakov et al.
Efficient analysis of large amounts of transcriptome data requires fast and easy access to raw gene expression data. In our work, we localized the available expression data of more than 50 000 genes in 54 tissues from approximately 1000 ind...
[Genetic Aspects of the Application of Tissue-Engineered Constructs in Regenerative Therapy in Cardiology: An Analytical Review] [0.03%]
[组织工程构建在心血管再生治疗中应用的遗传学问题分析性评述]
I S Kiselev,N A Matveeva,I B Beloglazova et al.
I S Kiselev et al.
Traditional methods of treatment and prevention of cardiovascular disease (CVD) are not always effective, especially in severe myocardial injury. One of the promising areas for the treatment of cardiac pathologies is cell transplantation us...
[Zinc-Dependent Histone Deacetylase (HDAC) Inhibitors: Therapeutic Potential, Pharmacophore Structure, and Methods for Testing Deacylase Activity] [0.03%]
锌依赖型组蛋白去乙酰酶(HDAC)抑制剂：治疗潜力、药效团结构及去酰基化活性检测方法
A S Zemskaya,S N Kochetkov,M V Kozlov
A S Zemskaya
In 1976, the antifungal hydroxamic antibiotic trichostatin A (TSA) was isolated from the metabolites of the bacterium Streptomyces hygroscopicus. It took 14 years to find that TSA has an effect on the proliferation and differentiation of ma...