[Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan]
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The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) removes various adducts from the 3'-end of DNA, including those induced by anticancer chemotherapeutics and is therefore considered an important therapeutic target. Previously, we investigated TDP1 ... ...
