[MARCKS-mediated regulation of exocytotic amylase release: involvement of membrane domain dynamics] [0.03%]
MARCKS介导的膜区动态变化调节糖原酶分泌作用机制研究
Keitaro Satoh,Yuta Ohno,Haruna Nagase
Keitaro Satoh
Salivary secretion is essential for maintaining oral and systemic health. In parotid acinar cells, activation of the cAMP-protein kinase A (PKA) pathway following β-adrenergic receptor stimulation triggers the exocytosis of amylase. Howeve...
Wataru Otsu,Junko Nio-Kobayashi
Wataru Otsu
[Reducing jet lag by "softening" the circadian clock: a study using transgenic rats expressing BMAL1-dominant negative proteins in the nervous system] [0.03%]
通过“软化”昼夜钟来减少时差反应——神经系统表达BMAL1显性负蛋白转基因大鼠的研究
Yoichi Minami,Yasufumi Shigeyoshi
Yoichi Minami
The circadian clock is an endogenous oscillator with a period of approximately 24 hours, with the central pacemaker localized in the suprachiasmatic nucleus (SCN). Jet lag occurs because the clock requires several days to entrain to a new e...
[Circadian clock gene-mediated regulation of chronic pain pathophysiology] [0.03%]
[昼夜钟基因介导的慢性疼痛病理生理调节]
Wakaba Yamakawa,Sai Yasukochi,Satoru Koyanagi
Wakaba Yamakawa
Many physiological functions in humans and other mammals exhibit circadian rhythms with an approximate 24-hour period, enabling efficient adaptation to periodic environmental changes driven by the Earth's rotation. Clock genes generate circ...
[Exploring for integrative signals guiding intracellular circadian clock synchronization: discovery of the BMAL1-ISR phenomenon] [0.03%]
探索整合细胞内生物钟同步信号的研究：发现BMAL1- ISR现象
Teruya Tamaru,Genki Kawamura,Atsuhiko Naito et al.
Teruya Tamaru et al.
Cell-autonomous circadian clocks are essential for organisms to adapt to daily environmental changes and optimize physiological timing. However, the common initial signaling events shared by diverse synchronizing cues-such as light, tempera...
Masaaki Ikeda
Masaaki Ikeda
Isshin Shiiba
Isshin Shiiba
Intracellular organelles do not function in isolation but instead cooperate through organelle contact sites, where membranes closely appose without fusion to exchange information and metabolites. Among these interfaces, mitochondria-endopla...
Ken-Ichi Wada
Ken-Ichi Wada
The mitochondrial genome (mtDNA) is a circular DNA of approximately 16.5 kbp, present at several thousand copies per cell. Although mtDNA is extremely small compared with the nuclear genome, it is quite important for life system because it ...
[Investigation of a causal relationship between mtDNA mutations and a mitochondrial respiratory dysfunction in premature aging mice] [0.03%]
线粒体DNA变异与早老小鼠呼吸链功能障碍的因果关系研究
Hiroaki Tamashiro,Kaori Ishikawa,Koichi Sadotomo et al.
Hiroaki Tamashiro et al.
The mitochondrial theory of aging has been proposed, which suggests that the accumulations of multiple in mtDNA with age induce decreased mitochondrial respiratory function, ultimately leading to aging. This hypothesis is widely accepted be...
Yuri Kato,Akiko Ogawa
Yuri Kato