[The role of the periaqueductal gray in behavioral selection under threat] [0.03%]
威胁下peri aqueductal灰质在行为选择中的作用
Natsuko Hitora-Imamura,Yuki Honshuku
Natsuko Hitora-Imamura
Fear responses and defensive behaviors are essential for survival, allowing animals to detect threatening stimuli and classify them as aversive. Neural circuits governing fear dynamically select adaptive defensive strategies, such as freezi...
[Current perspectives on the deep cerebellar nuclei in research on psychiatric and metabolic disorders] [0.03%]
有关深 cereb 脑核在精神病和代谢障碍研究的最新观点
Taiga Ishimoto,Chitoku Toda
Taiga Ishimoto
The cerebellum has historically been viewed as a key center for motor control and motor learning, with research primarily focusing on Purkinje cells as the core elements of its circuitry. However, accumulating evidence suggests a broader ro...
[Distinct prefrontal neuronal circuits determine repeated stress-induced behavioral styles in mice] [0.03%]
小鼠重复应激诱导的行为类型由不同的前额叶神经环路决定
Shusaku Uchida
Shusaku Uchida
Stressful experiences can initiate or exacerbate mental health conditions, including depression. Depression is a complex and diverse syndrome characterized by varying symptom profiles, progression patterns, and responses to treatment. Despi...
Yuki Takamura,Hiroshi Nomura
Yuki Takamura
Memory retrieval is not a static readout of fixed traces but a dynamic regulatory process where the accessibility of engrams, neuronal ensembles that are active during learning, fluctuates with internal and external states. Recent studies s...
Hiroshi Nomura
Hiroshi Nomura
Motoko Maekawa,Karina Kimura,Jinghang Fu et al.
Motoko Maekawa et al.
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates lipid metabolism and inflammatory responses. Recent studies have revealed that PPARα also plays an important role in maintaining neuronal homeostas...
[Therapeutic potential of histamine N-methyltransferase inhibition for the treatment of hypersomnia] [0.03%]
组胺N-甲基转移酶抑制治疗嗜睡症的潜力
Fumito Naganuma,Takeo Yoshikawa
Fumito Naganuma
Histamine plays a crucial role in maintaining wakefulness. Decreased histamine levels in the cerebrospinal fluid have been reported in patients with hypersomnia, including narcolepsy and idiopathic hypersomnia. Histamine N-methyltransferase...
[Identifying common neural circuit dysfunctions across psychiatric disorders through neurophysiological indices] [0.03%]
基于神经生理指标的精神疾病共通神经环路障碍的识别
Hideki Miwa
Hideki Miwa
The etiology of psychiatric disorders such as schizophrenia, autism spectrum disorder (ASD), and depression remains largely unknown, and to date, no clear diagnostic criteria or curative pharmacological treatments have been established. One...
[Application of ATP dynamics visualization in live mice to central nervous system diseases] [0.03%]
【应用在体小鼠ATP动态可视化技术研究中枢神经系统疾病】
Ryosuke Ochi,Masamichi Yamamoto
Ryosuke Ochi
Adenosine triphosphate (ATP) is a crucial molecule which is used not only as an energy source in living organisms but also as a signaling molecule in various biochemical reactions. Real-time measurement of ATP dynamics in vivo is necessary ...
Takeo Yoshikawa
Takeo Yoshikawa