Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime [0.03%]
1-（2-萘基）-2-（咪唑-1-基）乙酮肟的O-烷基化衍生物的合成及其抗惊厥活性研究
R Bansal,P Chauhan,R Sharma
R Bansal
In this study, O-alkylated derivatives of nafimidone oxime chemically, 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime have been synthesized as potential anticonvulsant compounds. O-alkylation of the oxime using hydrochlorides of various dia...
Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives [0.03%]
5-烷氧基-[1,2,4]三唑并吡啶衍生物的合成及抗惊厥活性研究
L-P Guan,R-P Zhang,Y Sun et al.
L-P Guan et al.
In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most pro...
Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study [0.03%]
氯沙坦氢氯噻嗪治疗氯沙坦为基础方案控制不佳的高血压的效果及对血浆B型钠尿肽浓度的影响：一项多中心前瞻性观察研究的事后分析
H Meno,T Inou,M Tanaka et al.
H Meno et al.
Many patients with hypertension have difficulty achieving their target blood pressure (BP). Therefore combination therapy, for example with an angiotensin II receptor blocker (ARB) and a diuretic, may be recommended. We previously evaluated...
Clinical Trial
Arzneimittel-Forschung. 2012 Sep;62(9):414-9. DOI:10.1055/s-0032-1316376 2012
Bioequivalence of acenocoumarol in chilean volunteers: an open, randomized, double-blind, single-dose, 2-period, and 2-sequence crossover study for 2 oral formulations [0.03%]
氯化安妥明在智利志愿者中的生物等效性：一种开放、随机、双盲、单剂量、两周期和两序列交叉研究的两种口服制剂
J Sasso,P Carmona,L Quiñones et al.
J Sasso et al.
The aim of this study was to compare the bioavailability of an oral formulation of the coumarin derivative-vitamine K antagonist acenocoumarol (Acebron™ 4 mg, Test) with the reference formulation (Neo-Sintrom™ 4 mg). We performed a single...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Aug;62(8):395-9. DOI:10.1055/s-0032-1316290 2012
Synthesis and cytotoxic activity of novel 3-methyl-1-[(4-substitutedpiperazin-1-yl)methyl]-1H-indole derivatives [0.03%]
新型3-甲基-1-[(4-取代哌嗪-1-基)甲基]-1H-吲哚衍生物的合成及其细胞毒性作用研究
M Koksal,M Yarim,I Durmaz et al.
M Koksal et al.
A series of novel 3-methyl-1-[(4-substitutedpiperazin-1-yl)methyl]-1H-indoles (3a-l) were synthesized and their cytotoxicities were analyzed against 3 different human cell lines, including liver (HUH7), breast (MCF7) and colon (HCT116). The...
Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide [0.03%]
胡椒碱对那格列奈抗高血糖作用及药代动力学特征的影响
V Sama,M Nadipelli,P Yenumula et al.
V Sama et al.
Piperine (CAS no: 94-62-2), an alkaloid obtained from Piper nigrum and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for biotransformation of drugs. By inhibiting the metabolism of drugs, piperine improves the...
Synthesis and anti-proliferative activity of substituted-anilinoquinazolines and its relation to EGFR inhibition [0.03%]
取代品烯氨基咔唑啉的合成及其抗增殖活性和EGFR抑制作用的关系研究
D A A El Ella,K A Saleh,M Hassan et al.
D A A El Ella et al.
4-Anilinoquinazoline is a privileged scaffold in developing small molecule inhibitors of tyrosine kinases (TK) especially epidermal growth factor receptor (EGFR). 2 series belonging to 3'-substituted-4-anilinoquinazoline scaffold were synth...
Systemic bioavailability of estriol following single and repeated vaginal administration of 0.03 mg estriol containing pessaries [0.03%]
含有雌三醇的阴道泡腾片单次和反复给药后全身生物利用度的研究（0.03mg）
K J Buhling,U Eydeler,S Borregaard et al.
K J Buhling et al.
A prospective monocentric open-label and single-arm trial was performed in 19 postmenopausal women with diagnosed vaginal atrophy. The aim was to determine the extent of a systemic exposure to estriol (CAS 50-27-1). Administration of estrio...
Clinical Trial
Arzneimittel-Forschung. 2012 Aug;62(8):378-83. DOI:10.1055/s-0032-1314822 2012
Validated LC-MS/MS method for the determination of mirodenafil in rat plasma and its application to a comparative pharmacokinetic study of the free base and hydrochloride salt forms of mirodenafil [0.03%]
用于测定mirodenafil大鼠血浆中含量的LC-MS / MS方法及其在游离碱和盐形式药物药代动力学比较研究中的应用
T K Kim,H H Yoo,J H Park
T K Kim
In this study, the pharmacokinetics of 2 forms of mirodenafil, namely the base form and the hydrochloride salt form, were investigated in rats. The 2 forms were orally administered to rats and the plasma concentrations of mirodenafil were d...
Comparative Study
Arzneimittel-Forschung. 2012 Jul;62(7):351-4. DOI:10.1055/s-0032-1312665 2012