Wirksamkeit und Verträglichkeit eines pflanzlichen Arzneimittels mit Kapuzinerkressenkraut und Meerrettich bei akuter Sinusitis, akuter Bronchitis und akuter Blasenentzündung im Vergleich zu anderen Therapien unter den Bedingungen der täglichen Praxis [0.03%]
与常规治疗相比，含紫锥菊和胡芦巴的植物药物在急性副鼻窦炎、急性支气管炎和急性膀胱炎患者中的疗效和耐受性：一项真实世界研究
Karl-Heinz Goos,Uwe Albrecht,Berthold Schneider
Karl-Heinz Goos
Leave-one-out procedure in the validation of elimination rate constant analysis [0.03%]
验证消除速率常数分析的留一法程序
T Grabowski,J J Jaroszewski,M Sasinowska-Motyl
T Grabowski
Many registration agencies and other organizations define how to calculate the elimination rate constant (kel) value. No validation procedures have been introduced to verify the correct selection of the concentration-time (C-T) points used ...
Pharmacokinetic and myocardial enzyme profiles of two administration routes of epirubicin in breast cancer patients [0.03%]
两种给药途径表柔比星在乳腺癌患者体内的药代动力学及心肌酶谱特征
R-X Yang,H-X Ren,L Zhuang et al.
R-X Yang et al.
To evaluate the changes in myocardial enzymes and plasma epirubicin concentration following administration by micro-pump (MP) and intravenous drip (ID) in breast cancer patients.11 self-controlled breast cancer patients were recruited for a...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):677-81. DOI:10.1055/s-0032-1331166 2012
Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer [0.03%]
一种新型血管紧张素IIAT1受体拮抗剂的合成、降压作用及其前列腺癌抗肿瘤活性研究
Y-J Da,W-D Yuan,L-F Zhu et al.
Y-J Da et al.
Since the first non-peptide Ang II receptor antagonist was originally reported, it has become the most common target in the development of new treatments for hypertension. In recent years, all components of the classical RAS have been repor...
Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine [0.03%]
关于沸石纳米材料和菊芋(Cynara scolymusL.)叶提取物对增加全身吸收尼古丁的尿液清除率的影响研究
R E Malekshah,R Mahjub,M Rastgarpanah et al.
R E Malekshah et al.
Nicotine, the main pharmacologically active component in tobacco and cigarette, has some toxic effects and also high potential for addiction. In this study, the effect of artichoke (Cynara scolymus L.) and zeolite nano-materials on urinary ...
Fluorescence detection of etoposide-loaded nanoparticles by HPLC and pharmacokinetics study [0.03%]
高效液相色谱法检测依托泊苷载药纳米粒并进行其体内动力学研究
H-Z Yang,L Liu,X Xu
H-Z Yang
A simple HPLC with fluorescence detection method was developed for determination and pharmacokinetic study of Etoposide in dog plasma.Plasma sample pretreatment involved liquid-liquid extraction of 500 µL plasma. The chromatographic separa...
Pharmacokinetics and potential advantages of a new oral solution of levothyroxine vs. other available dosage forms [0.03%]
莱索乐 Ventyl的药代动力学及其与已上市其他剂型相比的优势分析
C S Yue,C Scarsi,M P Ducharme
C S Yue
To better understand the pharmacokinetics and potential advantages of a levothyroxine oral solution vs. tablets and soft gel capsules.4 randomized, 2-treatment, single-dose (600 mcg levothyroxine), 2-way crossover bioequivalence studies in ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):631-6. DOI:10.1055/s-0032-1329951 2012
A validated HPLC method for the determination of eriocalyxin B in plasma and its application to pharmacokinetic studies [0.03%]
一种测定血浆中短毛金合欢素B的HPLC方法及其在药代动力学研究中的应用
Z Wang,Q Yuan,J-H Sun et al.
Z Wang et al.
The purpose of this study was to determine EriB in plasma by using the method of HPLC and collect the preclinical pharmacokinetic parameters of EriB.The analysis involved a simple liquid-liquid extraction. After making alkaline with NaOH, p...
Synthesis, biological activity and molecular modeling of 4-fluoro-N-[ω-(1,2,3,4-tetrahydroacridin-9-ylamino)-alkyl]-benzamide derivatives as cholinesterase inhibitors [0.03%]
作为乙酰胆碱酯酶抑制剂的4-氟-N-[ω-(1,2,3,4-四氢吖啶-9-基氨基)烷基]苯胺类化合物的合成、生物活性及分子模拟研究
P Szymański,M Markowicz,M Bajda et al.
P Szymański et al.
The aim of this study was to synthesize and determine the biological activity of new derivatives of 4-fluorobenzoic acid and tetrahydroacridine towards inhibition of cholinesterases. Compounds were synthesized in condensation reaction betwe...