scChat: A Large Language Model-Powered Co-Pilot for Contextualized Single-Cell RNA Sequencing Analysis [0.03%]
scChat：一种用于单细胞RNA测序分析的大型语言模型驱动的代码协同工具
Hsuan-Han Chiu,Ashley Varghese,Kunming Shao et al.
Hsuan-Han Chiu et al.
Single-cell RNA sequencing (scRNA-seq) has transformed biomedical research by enabling transcriptomic analysis at single-cell resolution. Yet, existing computational approaches remain primarily data-driven and lack the ability to integrate ...
Spheres, tears, and spears: Regulating the perimeter and circularity of millimeter-sized alginate hydrogel beads [0.03%]
藻酸盐水凝胶珠的尺寸、形状和结构调控研究进展
Conor G Harris,Katherine D Bandettini,Hannah K Gedde et al.
Conor G Harris et al.
Generating hydrogel beads pertains to many engineering applications. We examined two alginate-based fluids at three concentrations of alginate, c AG . We used the "Map of Misery" to determine which material property (viscosity, elasticit...
Ilias Mitrai,Victoria O Jones,Harman Dewantoro et al.
Ilias Mitrai et al.
The human brain is a complex system whose function depends on interactions between neurons and their ensembles across scales of organization. These interactions are restricted by anatomical and energetic constraints, and facilitate informat...
Differential Effects of Confinement-Induced ROS Accumulation on Highly Motile Cancerous and Non-Cancerous Cells [0.03%]
confinement诱导的ROS积累对高度活跃的癌细胞和非癌细胞的不同影响
William Collins Keith,Farnaz Hemmati,Ravi Sureshbhai Vaghasiya et al.
William Collins Keith et al.
In vivo, migrating cells often encounter microenvironments that impose spatial constraints, leading to cell and nuclear deformation. As confinement-induced DNA damage has been linked to the accumulation of reactive oxygen species (ROS), we ...
Daniel P Keane,Colby J Constantine,Matthew D Mellor et al.
Daniel P Keane et al.
The ability of nanoparticles to penetrate and transport through soft tissues is essential to delivering therapeutics to treat diseases or signaling agents for advanced imaging and sensing. Nanoparticle transport in biological systems, howev...
Multifunctional Porous Soft Composites for Bimodal Wearable Cardiac Monitors [0.03%]
用于双模式可穿戴心脏监测的多功能多孔软复合材料
Zehua Chen,Sicheng Chen,Syed Muntazir Andrabi et al.
Zehua Chen et al.
Wearable heart monitors are crucial for early diagnosis and treatment of heart diseases in non-clinical settings. However, their long-term applications require skin-interfaced materials that are ultrasoft, breathable, antibacterial, and pos...
Development and validation of a controlled heating apparatus for long-term MRI of 3D microfluidic tumor models [0.03%]
一种用于长期磁共振成像的三维微流体肿瘤模型的可控加热装置的研发与验证
Hassan Alkhadrawi,Kokeb Dese,Dhruvi M Panchal et al.
Hassan Alkhadrawi et al.
Conventional testing of novel contrast agents for magnetic resonance imaging (MRI) involves cell and animal studies. However, 2D cultures lack dynamic flow and in vivo MRI is limited by regulatory approval of long-term anesthesia use. Micro...
Quality-by-control of intensified continuous filtration-drying of active pharmaceutical ingredients [0.03%]
强化连续过滤干燥的药品活性成分的质量控制
Francesco Destro,Massimiliano Barolo,Zoltan K Nagy
Francesco Destro
Continuous manufacturing and closed-loop quality control are emerging technologies that are pivotal for next-generation pharmaceutical modernization. We develop a process control framework for a continuous carousel for integrated filtration...
Engineering a drug eluting ocular patch for delivery and sustained release of anti-inflammatory therapeutics [0.03%]
工程设计一种载药的眼用贴片用于抗炎药物的输送及持续释放
Xi Chen,Shima Gholizadeh,Mahsa Ghovvati et al.
Xi Chen et al.
Ocular inflammation is commonly associated with eye disease or injury. Effective and sustained ocular delivery of therapeutics remains a challenge due to the eye physiology and structural barriers. Herein, we engineered a photocrosslinkable...
Developing a machine learning enabled integrated formulation and process design framework for a pharmaceutical dropwise additive manufacturing printer [0.03%]
为具有滴加增材制造打印功能的制药设备开发一个机器学习赋能的配方和工艺设计平台
Varun Sundarkumar,Zoltan K Nagy,Gintaras V Reklaitis
Varun Sundarkumar
The pharmaceutical manufacturing sector needs to rapidly evolve to absorb the next wave of disruptive industrial innovations - Industry 4.0. This involves incorporating technologies like artificial intelligence, smart factories and 3D print...