The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation [0.03%]
同型半胱氨酸尿症相关的常见P1173L突变型人甲基钴胺素酶甲基化功能受损
Arkajit Guha,Ruma Banerjee
Arkajit Guha
The enzyme is susceptible to oxidative inactivation and is repaired by methionine synthase reductase (MTRR) in the presence of NADPH and S-adenosylmethionine (AdoMet).
Functional Characterization of MIP_07528 of Mycobacterium indicus pranii for Tyrosine Phosphatase Activity Displays Sensitivity to Oxidative Inactivation and Plays a Role in Immunomodulation [0.03%]
Mycobacterium indicus pranii的MIP_07528蛋白具有酪氨酸磷酸酶活性并参与免疫调节且易被氧化失活
Raunak Raunak,Roopshali Rakshit,Aayush Bahl et al.
Raunak Raunak et al.
The recombinant protein exhibited distinctive kinetic properties, characterized by higher substrate affinity yet increased susceptibility to oxidative inactivation compared to its M. tuberculosis counterpart.
Enzymatic saccharification of peat polysaccharides is limited by accessibility [0.03%]
peat多糖的酶促糖化受其可及性限制
Jonas Thomsen,Signe Lett,Helle J Martens et al.
Jonas Thomsen et al.
With an iron content of 2 g/kg dry peat, oxidative inactivation of enzymes is an important factor to take into account....A high inactivation constant of 125.91 x10-3 h-1 was found for the used saccharification conditions, but the addition of catalase alleviated the oxidative inactivation and increased the glucose yield with 60% in peat pretreated at 180 °C.
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature [0.03%]
细胞球蛋白能清除血管内的氢氧自由基并调节其信号分子的活性
Frances Jourd&#x;heuil,Clinton Mathai,Le Gia Cat Pham et al.
Frances Jourd&#x;heuil et al.
In addition, the ectopic expression of cytoglobin in cultured cells limited the inhibitory effect of H2O2 on glycolysis and reversed the oxidative inactivation of the glycolytic enzyme GAPDH. Cytoglobin facilitated the reduction of the thiol-based H2O2 sensor Hyper7 after H2O2 challenge.
Inactivation of human glucose 6-phosphate dehydrogenase (G6PDH) by peroxyl radicals is strongly modulated by its substrate and cofactor [0.03%]
过氧自由基通过底物和辅因子对人类葡萄糖-6-磷酸脱氢酶(G6PDH)的灭活作用强烈受到调节
Juan Sebastián Reyes,Eduardo Fuentes-Lemus,Angélica Fierro et al.
Juan Sebastián Reyes et al.
In the present work we report the oxidative inactivation of hG6PDH mediated by peroxyl radicals (ROO=) generated by AAPH (2,2'-azobis(2-methylpropionamidine) dihydrochloride) thermolysis. hG6PDH (46.4 μM, monomers) was incubated at 37 ºC with 10 or 100 mM AAPH.
Oroxylin A reverses SHP-2 oxidative inactivation in GPVI signaling to suppress platelet activation and thrombus formation [0.03%]
Oroxylin A通过逆转GPVI信号中的SHP-2氧化失活来抑制血小板激活和血栓形成
Yufei Chen,Yuan Lin,Jin Hong et al.
Yufei Chen et al.
Conclusions: OroA inhibits platelet activation, thrombus formation and myocardial injury via reversing SHP-2 oxidative inactivation thereby attenuating collagen-induced GPVI signaling.
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Impact of galectin-1's redox state on its lectin activity and monomer-dimer equilibrium. Focusing on oxidized Gal-1 [0.03%]
还原态和氧化态半乳糖凝集素-1的活性及寡聚形式的区别
Tatiana Staroňová,Jitka Holčáková,Petr Voňka et al.
Tatiana Staroňová et al.
Galectin-1 (Gal-1) displays unique sensitivity to oxidative inactivation which appears critical in regulating its spatial and temporal activity. The two physicochemical states, i.e. monomer-dimer equilibrium and redox states, are related to Gal-1 varying functionality.
Redox remodeling of central metabolism as a driving force for cellular protection, proliferation, differentiation, and dysfunction [0.03%]
中枢代谢的氧化还原重构是细胞保护、增殖、分化和功能障碍的主要驱动力
Junichi Fujii
Junichi Fujii
On the other hand, oxidative inactivation of mitochondrial aconitase increases citrate, which is then recruited to synthesize fatty acids in the cytoplasm.
Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement [0.03%]
底物依赖型氧化失活作用涉及硒代半胱氨酸置换的W-型甲醛脱氢酶氧化失活作用
Guilherme Vilela-Alves,Rita R Manuel,Aldino Viegas et al.
Guilherme Vilela-Alves et al.
Metal-dependent formate dehydrogenases are very promising targets for enzyme optimization and design of bio-inspired catalysts for CO2 reduction, towards innovative strategies for climate change mitigation. For effective application of thes...
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