Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature [0.03%]
细胞球蛋白能清除血管内的氢氧自由基并调节其信号分子的活性
Frances Jourd&#x;heuil,Clinton Mathai,Le Gia Cat Pham et al.
Frances Jourd&#x;heuil et al.
In addition, the ectopic expression of cytoglobin in cultured cells limited the inhibitory effect of H2O2 on glycolysis and reversed the oxidative inactivation of the glycolytic enzyme GAPDH. Cytoglobin facilitated the reduction of the thiol-based H2O2 sensor Hyper7 after H2O2 challenge.
Inactivation of human glucose 6-phosphate dehydrogenase (G6PDH) by peroxyl radicals is strongly modulated by its substrate and cofactor [0.03%]
过氧自由基通过底物和辅因子对人类葡萄糖-6-磷酸脱氢酶(G6PDH)的灭活作用强烈受到调节
Juan Sebastián Reyes,Eduardo Fuentes-Lemus,Angélica Fierro et al.
Juan Sebastián Reyes et al.
In the present work we report the oxidative inactivation of hG6PDH mediated by peroxyl radicals (ROO=) generated by AAPH (2,2'-azobis(2-methylpropionamidine) dihydrochloride) thermolysis. hG6PDH (46.4 μM, monomers) was incubated at 37 ºC with 10 or 100 mM AAPH.
Oroxylin A reverses SHP-2 oxidative inactivation in GPVI signaling to suppress platelet activation and thrombus formation [0.03%]
Oroxylin A通过逆转GPVI信号中的SHP-2氧化失活来抑制血小板激活和血栓形成
Yufei Chen,Yuan Lin,Jin Hong et al.
Yufei Chen et al.
Conclusions: OroA inhibits platelet activation, thrombus formation and myocardial injury via reversing SHP-2 oxidative inactivation thereby attenuating collagen-induced GPVI signaling.
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Impact of galectin-1's redox state on its lectin activity and monomer-dimer equilibrium. Focusing on oxidized Gal-1 [0.03%]
还原态和氧化态半乳糖凝集素-1的活性及寡聚形式的区别
Tatiana Staroňová,Jitka Holčáková,Petr Voňka et al.
Tatiana Staroňová et al.
Galectin-1 (Gal-1) displays unique sensitivity to oxidative inactivation which appears critical in regulating its spatial and temporal activity. The two physicochemical states, i.e. monomer-dimer equilibrium and redox states, are related to Gal-1 varying functionality.
Redox remodeling of central metabolism as a driving force for cellular protection, proliferation, differentiation, and dysfunction [0.03%]
中枢代谢的氧化还原重构是细胞保护、增殖、分化和功能障碍的主要驱动力
Junichi Fujii
Junichi Fujii
On the other hand, oxidative inactivation of mitochondrial aconitase increases citrate, which is then recruited to synthesize fatty acids in the cytoplasm.
Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement [0.03%]
底物依赖型氧化失活作用涉及硒代半胱氨酸置换的W-型甲醛脱氢酶氧化失活作用
Guilherme Vilela-Alves,Rita R Manuel,Aldino Viegas et al.
Guilherme Vilela-Alves et al.
Metal-dependent formate dehydrogenases are very promising targets for enzyme optimization and design of bio-inspired catalysts for CO2 reduction, towards innovative strategies for climate change mitigation. For effective application of thes...
Enhanced Photobiocatalytic Cascades at Pickering Droplet Interfaces [0.03%]
Pickering乳液界面增强光生物催化级联反应
Ke Li,Houbing Zou,Xili Tong et al.
Ke Li et al.
It was demonstrated that spatial localization of the photocatalyst and the enzyme at Pickering oil droplet interfaces not only provided their respective preferable reaction environments and intimate proximity for rapid H2O2 transport but also protected the enzyme from oxidative inactivation caused by
Competitive oxidation of key pentose phosphate pathway enzymes modulates the fate of intermediates and NAPDH production [0.03%]
关键戊糖磷酸途径酶的竞争性氧化调控中间代谢物的命运和NADPH的产生
Juan Sebastián Reyes,Javiera Cortés-Ríos,Eduardo Fuentes-Lemus et al.
Juan Sebastián Reyes et al.
We have previously studied peroxyl radical (ROO•) mediated oxidative inactivation of E. coli G6PDH, 6PGL, and 6PGDH. However, these data were obtained from experiments where each enzyme was independently exposed to ROO•, a condition not reflecting biological reality.
Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis [0.03%]
脑膜炎奈瑟氏球菌中蛋白酪氨酸磷酸酶NMA1982的活性机制研究及其潜在致病性因子作用分析
Shuangding Wu,Mathieu Coureuil,Xavier Nassif et al.
Shuangding Wu et al.
Mutagenesis experiments, transition state inhibition, pH-dependence activity, and oxidative inactivation experiments all support that NMA1982 is a genuine PTP. Importantly, we show that NMA1982 is secreted by N. meningitidis, suggesting that this protein is a potential virulence factor.
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