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The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation

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Human methionine synthase (MTR) is a cobalamin-dependent enzyme, which catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine to form methionine and tetrahydrofolate. The enzyme is susceptible to oxidative inactivation and is repa... ...