Virological success despite archived INSTI drug resistance mutations on INSTI-based antiretroviral regimens [0.03%]
INSTI耐药突变对基于INSTI的抗逆转录病毒治疗方案疗效的影响
Yanis Merad,Alice-Andrée Mariaggi,Marina Karmochkine et al.
Yanis Merad et al.
No virologic failure occurred on INSTI-based therapy during a median follow-up of 202 days (IQR: 105-366).
HIV viral suppression after enhanced adherence counselling in children on dolutegravir-based regimens in Malawi [0.03%]
马拉维接受多替拉韦为基础治疗方案的儿童在加强服药依从性咨询后的 HIV 病毒抑制情况
Lucky Makonokaya,Maggie Khumbanyiwa,Louiser U Kalitera et al.
Lucky Makonokaya et al.
Further research on the other contributors of virologic failure among children in Malawi is required.
Cost-Effectiveness of an Enhanced Patient Care Intervention for Improving Viral Suppression Among Kenyan Adults Living With HIV [0.03%]
在肯尼亚提高HIV感染者病毒抑制率的增强型患者护理干预的成本效益分析
Jenna Fritz,Juddy Wachira,Marta Wilson-Barthes et al.
Jenna Fritz et al.
The incremental cost per disability-adjusted life year averted was calculated based on patient virologic failure risk, HIV transmissions averted, and life expectancy.
Viral load dynamics among adults receiving HIV care in rural North-Eastern South Africa, 2015-2020: insights from a population-based record linkage study [0.03%]
2015年至2020年南非东北部农村HIV治疗成年人的病毒载量变化:人口为基础的记录链接研究的新见解
Armstrong Dzomba,Francesc Xavier Gomez-Olive,Jean Bashingwa et al.
Armstrong Dzomba et al.
The likelihood of achieving viral suppression was high among men, those aged 15-24 years and 25-34 years however, these groups were less likely to have sustained viral suppression and more likely to experience virologic failure and rebounding.
Low-level viraemia as a risk factor for virologic failure in children and adolescents living with HIV on antiretroviral therapy in Tanzania: a multicentre, retrospective cohort study [0.03%]
坦桑尼亚接受抗逆转录病毒治疗的儿童和青少年中低水平血浆病毒载量是病毒学失败的风险因素:一项多中心回顾性队列研究
Kevin P McKenzie,Duc T Nguyen,Lilian B Komba et al.
Kevin P McKenzie et al.
Introduction: Viral load (VL) of 1000 copies/ml or greater is commonly used to define virologic failure (VF) in children and adolescents living with HIV (CALHIV) in low- and middle-income countries (LMICs).
Multicenter Study
Journal of the International AIDS Society. 2025 May;28(5):e26474. DOI:10.1002/jia2.26474 2025
HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia [0.03%]
利比里亚抗逆转录病毒经治艾滋病病毒感染者的HIV-1抑制和罕见的多替拉韦耐药性
James Soka Moses,Alice K Pau,Safia Kuriakose et al.
James Soka Moses et al.
Background: Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown...Methods: Cross-sectional analysis of 2019-2022 enrolment data from 1276 persons with HIV in the HONOR cohort included sociodemographic information, plasma viral loads (pVL), CD4 counts, and HIVDR testing by next generation sequencing in participants with virologic failure (pVL≥1000
Incidence and factors associated with HIV virologic failure among adults on first-line antiretroviral therapy: A five-year retrospective study in Thailand [0.03%]
泰国初治艾滋病患者一线抗病毒治疗失败的发病率及影响因素五年的回顾性研究
Lantharita Charoenpong,Chalor Santiwarangkana,Weerawat Manosuthi
Lantharita Charoenpong
To determine the cumulative incidence rate of virologic failure and related factors, all PLWHs were monitored for viral load status through December 2019. Virologic failure was defined as HIV viral load >1,000 copies/mL after 6 months of ART....The Cox proportional hazard model revealed that the risk of developing virologic failure was significantly associated with age < 30 years and baseline CD4 cell count ≤ 200 cells/mm 3 .
Effect of Machine Learning on Risk Stratification for Antiretroviral Treatment Failure in People Living with HIV [0.03%]
机器学习对HIV携带者抗逆转录病毒治疗失败风险分类的影响
Wenyuan Zhang,Lehao Ren,Kai Yang et al.
Wenyuan Zhang et al.
Objective: Despite the widespread use of antiretroviral therapy (ART), HIV virologic failure remains a significant global public health challenge....This study aims to develop and validate a nomogram-based scoring system to predict the incidence and determinants of virologic failure in people living with HIV (PLWH), facilitating timely interventions and reducing unnecessary transitions to second-line regimens....Conclusion: This novel model provides an accurate, well-calibrated tool for predicting virologic failure at the individual level, offering valuable clinical utility in optimizing HIV management.
Mortality, loss to follow-up and advanced HIV disease following virologic success in West African HIV-2 patients [0.03%]
西非艾滋病患者病毒学成功后的死亡率、失访和疾病晚期化状况(HIV-2)
Jean J Koffi,Simon P Boni,Lionèle Mba et al.
Jean J Koffi et al.
Advanced HIV disease followed WHO definition and virologic failure was define as viral load > 50 copies/mm3. The Kaplan-Meier curve was used to estimate mortality and Loss to follow-up probability.
Predicted dolutegravir resistance in people living with HIV in South Africa during 2020-35: a modelling study [0.03%]
在2020-2035年期间南非HIV感染者预测的多替拉韦耐药性:建模研究
Tom Loosli,Nuri Han,Anthony Hauser et al.
Tom Loosli et al.
transcriptase inhibitors on dolutegravir-resistance acquisition, the effect of dolutegravir resistance on dolutegravir-treatment efficacy, the probability of transmitting dolutegravir drug-resistance mutations compared with the probability of transmitting wild-type HIV, and the proportion of people with virologic...failure on dolutegravir-based antiretroviral therapy with detectable drug levels.
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