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Yanis Merad,Alice-Andrée Mariaggi,Marina Karmochkine et al. Yanis Merad et al.
No virologic failure occurred on INSTI-based therapy during a median follow-up of 202 days (IQR: 105-366).
Jenna Fritz,Juddy Wachira,Marta Wilson-Barthes et al. Jenna Fritz et al.
The incremental cost per disability-adjusted life year averted was calculated based on patient virologic failure risk, HIV transmissions averted, and life expectancy.
Armstrong Dzomba,Francesc Xavier Gomez-Olive,Jean Bashingwa et al. Armstrong Dzomba et al.
The likelihood of achieving viral suppression was high among men, those aged 15-24 years and 25-34 years however, these groups were less likely to have sustained viral suppression and more likely to experience virologic failure and rebounding.
Kevin P McKenzie,Duc T Nguyen,Lilian B Komba et al. Kevin P McKenzie et al.
Introduction: Viral load (VL) of 1000 copies/ml or greater is commonly used to define virologic failure (VF) in children and adolescents living with HIV (CALHIV) in low- and middle-income countries (LMICs).
James Soka Moses,Alice K Pau,Safia Kuriakose et al. James Soka Moses et al.
Background: Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown...Methods: Cross-sectional analysis of 2019-2022 enrolment data from 1276 persons with HIV in the HONOR cohort included sociodemographic information, plasma viral loads (pVL), CD4 counts, and HIVDR testing by next generation sequencing in participants with virologic failure (pVL≥1000
Lantharita Charoenpong,Chalor Santiwarangkana,Weerawat Manosuthi Lantharita Charoenpong
To determine the cumulative incidence rate of virologic failure and related factors, all PLWHs were monitored for viral load status through December 2019. Virologic failure was defined as HIV viral load >1,000 copies/mL after 6 months of ART....The Cox proportional hazard model revealed that the risk of developing virologic failure was significantly associated with age < 30 years and baseline CD4 cell count ≤ 200 cells/mm 3 .
Wenyuan Zhang,Lehao Ren,Kai Yang et al. Wenyuan Zhang et al.
Objective: Despite the widespread use of antiretroviral therapy (ART), HIV virologic failure remains a significant global public health challenge....This study aims to develop and validate a nomogram-based scoring system to predict the incidence and determinants of virologic failure in people living with HIV (PLWH), facilitating timely interventions and reducing unnecessary transitions to second-line regimens....Conclusion: This novel model provides an accurate, well-calibrated tool for predicting virologic failure at the individual level, offering valuable clinical utility in optimizing HIV management.
Jean J Koffi,Simon P Boni,Lionèle Mba et al. Jean J Koffi et al.
Advanced HIV disease followed WHO definition and virologic failure was define as viral load > 50 copies/mm3. The Kaplan-Meier curve was used to estimate mortality and Loss to follow-up probability.
Tom Loosli,Nuri Han,Anthony Hauser et al. Tom Loosli et al.
transcriptase inhibitors on dolutegravir-resistance acquisition, the effect of dolutegravir resistance on dolutegravir-treatment efficacy, the probability of transmitting dolutegravir drug-resistance mutations compared with the probability of transmitting wild-type HIV, and the proportion of people with virologic...failure on dolutegravir-based antiretroviral therapy with detectable drug levels.
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