Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation [0.03%]
SARS-CoV-2 N蛋白动态集合体揭示了头对头的螺旋桨驱动聚类和相分离
Guillem Hernandez,Maria L Martins,Nuno P Fernandes et al.
Guillem Hernandez et al.
The SARS-CoV-2 nucleocapsid (N) protein is essential for the viral life cycle, facilitating RNA packaging, replication, and host-cell interactions. Its ability to self-assemble and undergo phase separation is critical for these functions bu...
SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain [0.03%]
SARS-CoV-2 N蛋白与Nav1.7相互作用以促进病理性疼痛
Jin-Kun Liu,Zi-Su Zhou,Shu-Hang Wang et al.
Jin-Kun Liu et al.
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis, with many patients experiencing not only acute neurological and sensory symptoms but also pe...
SARS-CoV-2 N protein exerts antitumor effects in NSCLC by inducing DNA damage and augmenting chemotherapeutic sensitivity [0.03%]
新型冠状病毒N蛋白通过诱导DNA损伤和增强化疗敏感性在非小细胞肺癌中发挥抗肿瘤作用
Xin Wang,Fang Cao,Di Chen et al.
Xin Wang et al.
Recently, we reported that the SARS-CoV-2 nucleocapsid (N) protein triggers DNA damage by inducing autophagic degradation of RNAi components (Dicer and XPO5) and splicing factors (SRSF3 and hnRNPA3). In this study, we found that the SARS-Co...
SARS-CoV-2 N protein interacts with SLC7A11 to cause ferroptosis in acute lung injury [0.03%]
SARS-CoV-2 N蛋白通过与SLC7A11相互作用引起急性肺损伤铁死亡
Yi Liu,Hui Tang,Pan Xu et al.
Yi Liu et al.
Background: The nucleocapsid protein (N protein) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is elevated in bodily fluids at the onset of infection and has recently been found to have a direct role in ...
Construction and immunogenicity analysis of a recombinant baculovirus targeting the N protein of SARS-CoV-2 [0.03%]
SARS-CoV-2 N蛋白靶向重组杆状病毒的构建及其免疫原性分析
Bohan Yu,Xiaoli Mo,Li Sui et al.
Bohan Yu et al.
Objectives: This study aimed to construct recombinant baculoviruses capable of expressing the nucleocapsid N protein of SARS-CoV-2 and to assess the effects of co-administration with sodium butyrate on its expression and ...
Optimization of A549 Cell Transfection Efficiency with a Plasmid Encoding the N-Protein of the SARS-CoV-2 Virus [0.03%]
含SARS-CoV-2 N蛋白质粒的A549细胞转染效率优化研究
Yu V Khramtsov,T N Lupanova,A A Rosenkranz et al.
Yu V Khramtsov et al.
To test new antiviral drugs aimed at degrading the nucleocapsid protein (N-protein) of the SARS-CoV-2 virus, it is desirable to have cells expressing the N-protein, for which it is necessary to find conditions for the maximum achievable eff...
Distinct roles of SARS-CoV-2 N protein and NFP in host cell response modulation [0.03%]
SARS-CoV-2的N蛋白和NFP在调节宿主细胞反应中的不同作用
Hsin-Chi Lan,Bo-Yi Hou,Shu-Ting Chang et al.
Hsin-Chi Lan et al.
The SARS-CoV-2 nucleocapsid (N) protein is crucial for viral replication and modulation of host cell responses. Here, we identify and characterize a novel N-fusion protein, designated NFP. NFP is derived from an alternative open reading fra...
Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice [0.03%]
携带SARS-CoV-2 N蛋白的流感载体粘膜免疫保护易感小鼠并防止血清阳性小鼠出现疾病加重现象
Mariia V Sergeeva,Kirill Vasilev,Ekaterina Romanovskaya-Romanko et al.
Mariia V Sergeeva et al.
Background/Objectives: Intranasal vaccination enhances protection against respiratory viruses by providing stimuli to the immune system at the primary site of infection, promoting a balanced and effective response. Influenza vectors with tr...
Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA [0.03%]
不含亲和标签的SARS-CoV-2 N蛋白纯化及其与单链DNA复合物的晶体结构解析
Atanu Maiti,Hiroshi Matsuo
Atanu Maiti
The nucleocapsid (N) protein is one of the four structural proteins in SARS-CoV-2, playing key roles in viral assembly, immune evasion, and stability. One of its primary functions is to protect viral RNA by forming the nucleocapsid. However...
SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs [0.03%]
SARS-CoV-2 N蛋白招募G3BP到双层膜囊泡以促进病毒mRNA的翻译
Siwen Long,Mykhailo Guzyk,Laura Perez Vidakovics et al.
Siwen Long et al.
Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) protein exhibits strong binding affinit...
耗时 0.09256 秒，为您在
48229835
条记录里面共找到 72 篇文章 [XML]