CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential [0.03%]
乳腺癌进展中的CCR4-_NOT转录复合物亚基7(CNOT7)蛋白与白细胞相关免疫球蛋白样受体-1的临床机制洞察及基于计算的治疗潜力分析
Mona M Elanany,Dina Mostafa,Ahmad A Hady et al.
Mona M Elanany et al.
Metastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progr...
Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin [0.03%]
三联蛋白通过与CCR4-NOT和PABPC1的多价相互作用决定其对mRNA的抑制效率
Filip Pekovic,Wi S Lai,Joshua Corbo et al.
Filip Pekovic et al.
Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation. The CCR4-NOT co...
TOB Proteins Repress Translation via the CCR4-NOT Deadenylase Complex Independent of Deadenylation [0.03%]
TOB蛋白通过CCR4-NOT去腺苷酸酶复合物独立于去腺苷酸化抑制翻译
Kanae Miyazaki,Takumi Tomohiro,Yoshinori Funakami et al.
Kanae Miyazaki et al.
Transducer of ErbB2 (TOB) proteins have been shown to promote mRNA decay through interactions with the CCR4-NOT complex and poly(A)-binding protein (PABP). While their role in deadenylation-mediated mRNA degradation is well established, the...
Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling [0.03%]
CNOT1-CCR4-NOT是53BP1-p53-p21信号传导的抑制因子
Antonio Galarreta,Virginia Pasti,Julia Vornberger et al.
Antonio Galarreta et al.
Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation...
Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex [0.03%]
胰岛素降解酶调控信使RNA处理及其可能与CCR4-NOT复合物相互作用
Barbara Bertocci,Ayse Yilmaz,Emmanuelle Waeckel-Énée et al.
Barbara Bertocci et al.
Insulin-degrading enzyme is a zinc metalloprotease that degrades low-molecular-weight substrates, including insulin. Ubiquitous expression, high evolutionary conservation, upregulation of Ide in stress situations, and literature findings su...
RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4-NOT and Promote Cell Proliferation [0.03%]
RING指突变体驱动蛋白质相分离以包裹CCR4-NOT促进细胞增殖
Chen Chen,Chenghao Guo,Ke Fang et al.
Chen Chen et al.
RING finger protein 219 (RNF219) is a co-factor for the CCR4-NOT deadenylase complex in mammals. Here, we found that mutations within the C3HC4 scaffold of the RING finger domain in RNF219 are capable of forming condensates via liquid-liqui...
Knockdown of CNOT3, a subunit of the CCR4-NOT deadenylase complex, sensitizes A549 human non-small cell lung cancer cells to senescence-inducing stimuli [0.03%]
CNOT3基因敲低通过诱导衰老增强A549细胞对促衰老刺激的敏感性
Aisulu Maipas,Atsuko Sato,Yohsuke Moriyama et al.
Aisulu Maipas et al.
Cellular senescence is an essentially irreversible cell cycle arrest associated with upregulated inflammatory responses that contribute to various pathological and physiological processes, including aging, cancer, and cancer prevention. How...
Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex [0.03%]
锌通过CCR4-NOT复合物调节模式真菌裂殖酵母sod1 mRNA和蛋白质的丰度
Andrew T Weeks,Amanda J Bird
Andrew T Weeks
Zinc is an essential micronutrient that serves as a cofactor in a wide variety of enzymes, including Cu-Zn Superoxide Dismutase 1 (Sod1). We have discovered in Schizosaccharomyces pombe that Sod1 mRNA and protein levels are regulated in res...
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA [0.03%]
MARTRE蛋白通过抑制CCR4-NOT活性来保护多聚腺苷酸尾长度并促进母源mRNA的翻译
Jing Yang,Jiachen Bu,Bowen Liu et al.
Jing Yang et al.
The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regu...
The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT [0.03%]
铜绿假单胞菌效应蛋白PieF通过与真核CCR4-NOT相互作用来调控信使rna稳定性
Harley O&#x;Connor Mount,Malene L Urbanus,Francesco Zangari et al.
Harley O&#x;Connor Mount et al.
The eukaryotic CCR4-NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen. We show that a tra...
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