Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin
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Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation. The CCR4-NOT complex plays a centra... ...
