Dearomatization of Electron-Deficient Indoles with N-Alkylanilines via Visible-Light-Induced Hydroalkylation [0.03%]
可见光诱导下N-烷基苯胺与电子贫乏吲哚的去芳构化氢烷基化反应
Qiao Zhang,Haibo Shan,Qihang Xu et al.
Qiao Zhang et al.
Herein, a visible-light-induced, base-promoted 3 + 2 annulation was developed for the dearomatization of electron-deficient indoles with readily available N-alkylanilines, affording valuable tetrahydropyrrolo[3,4-b]indol-1(2H)-ones with hig...
Enantioconvergent Cobalt-Catalyzed Hydroalkylation for the Construction of Fluoro-, Chloro-, and Trifluoromethyl Stereogenic Centers [0.03%]
用于构建氟、氯和三氟甲基立体中心的对映汇聚型钴催化氢烷基化反应
Uttam Dhawa,Xile Hu
Uttam Dhawa
Organic compounds containing a chiral, halogenated aliphatic carbon center are useful in medicinal chemistry, but their enantioselective synthesis remains difficult. Here we develop a general approach to access these compounds through cobal...
Ni-H-Catalyzed Regioselective Hydroalkylation of Terminal Alkynes with α-Bromo Phosphonates [0.03%]
镍氢催化的末端炔烃与α-溴磷onic酯的区域选择性加成氢烷基化反应
Huimin Yang,Niannian Li,Jiayan Jin et al.
Huimin Yang et al.
We present here a versatile and efficient Ni-H-catalyzed hydroalkylation reaction of terminal alkynes and α-bromo phosphonates with Markovnikov selectivity, yielding a range of allylic phosphate terminal alkenes. This reaction demonstrates...
Mild Hydroalkylation of Terminal Olefins Via Decatungstate/Thiol Cooperative Photocatalysis [0.03%]
基于十钨酸盐/硫醇光催化体系的末端烯烃自由基氢官能团化反应
Austin J Moser,Paige E Sutter,Alex M Chavez et al.
Austin J Moser et al.
Here we report the use of a tetrabutylammonium decatungstate (TBADT)/thiol photocatalytic system for selective addition of acetone and other simple ketone, nitrile, and chlorocarbon functionalities to terminal olefins. This system avoids th...
β-Quaternary α-Amino Acids via Iridium-Catalyzed Branched and Enantioselective Hydroalkylation of 1,1-Disubstituted Styrenes [0.03%]
Ir催化的1,1-位取代苯乙烯的分支及对映选择性氢官能化反应合成β-四级α-氨基酸
Fenglin Hong,L Anders Hammarback,Yihong Wang et al.
Fenglin Hong et al.
A cationic Ir(I)-complex modified with the chiral diphosphine DM-SEGPHOS mediates the hydroalkylation of diverse α-methyl styrenes with N-aryl glycine derivatives. The processes occur with complete branched selectivity and high enantiosele...
Photoredox-Catalyzed Radical Hydroalkylation of Azobenzenes with Alkylboronic Acids [0.03%]
光氧化还原催化偶氮苯与烷基硼酸的自由基加成氢烷基化反应
Jiangjiang Li,Hongyan Zhou,Shouying Mei et al.
Jiangjiang Li et al.
The facile synthesis of N-alkyl-N,N'-diarylhydrazines has been a long-standing challenge. Here, we report a photoredox-catalyzed hydroalkylation of azobenzenes with alkylboronic acids, which successfully affords diverse N-alkyl-N,N'-diarylh...
Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation [0.03%]
手性和非对映选择性合成P-手性磷烷氧化物的研究进展：钴催化氢官能团化反应路径
Dao-Yong Zhu,Ya-Ting Zhang,Fu Cheng et al.
Dao-Yong Zhu et al.
Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis and synthesis. However, the construction of the chiral phospholane skeleton remains challenging and primarily relies on the use of chiral auxiliaries ...
Avery O Morris,Tegan E O&#x;Brien,Louis Barriault
Avery O Morris
We present a detailed study on a photoredox catalysis platform that directly engages 1,3-dicarbonyl C(sp3)-H acids towards radical reactions. This platform enables redox-neutral hydroalkylation and cross-coupling, as well as oxidative trans...
Photocatalytic hydroalkylation of 3-methyleneisoindolin-1-ones with unactivated alkyl iodides [0.03%]
非活化碘代烷与3-亚甲基异吲哚-1-酮的光催化加氢烷基化反应
Abhishek Kumar,Shrutheka G S,Veera Reddy Yatham
Abhishek Kumar
We report herein a simple method for hydroalkylation of 3-methyleneisoindolin-1-ones with unactivated iodoalkanes using visible light photocatalysis and a halogen atom transfer (XAT) process. This operationally simple method exhibits broad ...
CuH-Catalyzed Regio- and Enantioselective Hydroallylation of 1-Trifluoromethylthioalkenes: Leaving Group-Dependent Stereochemistry [0.03%]
1-三氟甲硫代烯烃的CuH催化的区域和对映选择性氢烷基化：离去基团依赖立体化学
Yuki Kojima,Shinichi Suda,Wataru Kanna et al.
Yuki Kojima et al.
A copper-catalyzed regio- and enantioselective hydroallylation of 1-trifluoromethylthioalkenes with hydrosilanes and allylic electrophiles has been developed. The judicious choice of chiral ligands successfully promotes the enantioselective...
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