We present here a versatile and efficient Ni-H-catalyzed hydroalkylation reaction of terminal alkynes and α-bromo phosphonates with Markovnikov selectivity, yielding a range of allylic phosphate terminal alkenes. This reaction demonstrates a broad substrate scope and excellent functional group compatibility, including those with complex structural motifs found in natural products and pharmaceuticals. The practical applicability is demonstrated through gram-scale reactions and product transformations. In addition, the methodology is also applicable to the substrates of benzyl bromides and bromo amides.
Organic letters. 2025 May 29. doi: 10.1021/acs.orglett.5c01555 Q15.02025
Ni-H-Catalyzed Regioselective Hydroalkylation of Terminal Alkynes with α-Bromo Phosphonates
镍氢催化的末端炔烃与α-溴磷onic酯的区域选择性加成氢烷基化反应 翻译改进
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DOI: 10.1021/acs.orglett.5c01555 PMID: 40438913
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