Chemical communications (Cambridge, England). 2025 Jan 2;61(3):580-583. doi: 10.1039/d4cc04842c Q24.22025

Controllable multivalent LYTACs enhance targeted protein degradation

可控的多价LYTACs增强目标蛋白质降解翻译改进

Yuheng Lv¹, Yicun Li¹, Qin Fu¹, Peng Shi^{1 2 3}

作者单位 +展开

作者单位

¹ School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, P. R. China. pxs301@scut.edu.cn.

² National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P. R. China.

³ Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.

DOI: 10.1039/d4cc04842c PMID: 39656158

摘要中英对照阅读

We present a versatile DNA-based LYTAC framework that allows control over the valency of chimeras and the distance between ligands through DNA self-assembly. By evaluating the degradation capabilities of LYTACs with 1, 3, and 9 valences, we confirm the broad applicability of the multivalent enhancement effect across different lysosome-targeting receptor-mediated degradation pathways. Our findings provide valuable insights into improving the degradation efficiency of LYTACs.

Keywords：targeted protein degradation

我们提出了一种多功能的基于DNA的LYTAC框架，可以通过DNA自我组装来控制嵌合体的价态和配体之间的距离。通过评估具有1、3和9个价态的LYTACs的降解能力，我们确认了多价增强效应在不同溶酶体靶向受体介导的降解途径中的广泛应用性。我们的研究结果为提高LYTACs的降解效率提供了宝贵的见解。

关键词：可控多价LYTACs; 靶向蛋白降解

翻译效果不满意？用Ai改进或寻求AI助手帮助，对摘要进行重点提炼

相关内容

期刊名：Chemical communications

缩写：CHEM COMMUN

ISSN：1359-7345

e-ISSN：1364-548X

IF/分区：4.2/Q2

文章目录更多期刊信息

全文链接

官方链接

PMC全文

引文链接

复制

已复制！

格式：

Controllable multivalent LYTACs enhance targeted protein degradation

可控的多价LYTACs增强目标蛋白质降解翻译改进

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

超越传统PROTAC：生物靶向蛋白质降解技术（BioTPD）

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

利用Culine E3连接酶衔接蛋白SKP1进行靶向蛋白质降解

Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling

通过快速光遗传学激活实现蛋白质降解及其在细胞信号控制中的应用

Harnessing UBR5 for targeted protein degradation of key transcriptional regulators

利用UBR5实现关键转录调节因子的靶向蛋白降解

Progress and Challenges in Targeted Protein Degradation for Neurodegenerative Disease Therapy

靶向蛋白降解在神经退行性疾病治疗中的进展与挑战

Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation

CRL2ZYG11B E3连接酶的非抑制性配体适体的识别以实现靶向蛋白质降解

Targeted protein degradation: Emerging concepts and protein state-specific targeting principles

蛋白质降解的靶向调控：新兴概念及面向蛋白质特性的靶向原则

Targeted protein degradation through light-activated E3 ligase recruitment

光激活E3连接酶募集促目标蛋白降解

Controllable multivalent LYTACs enhance targeted protein degradation

可控的多价LYTACs增强目标蛋白质降解 翻译改进

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

超越传统PROTAC：生物靶向蛋白质降解技术（BioTPD）

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

利用Culine E3连接酶衔接蛋白SKP1进行靶向蛋白质降解

Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling

通过快速光遗传学激活实现蛋白质降解及其在细胞信号控制中的应用

Harnessing UBR5 for targeted protein degradation of key transcriptional regulators

利用UBR5实现关键转录调节因子的靶向蛋白降解

Progress and Challenges in Targeted Protein Degradation for Neurodegenerative Disease Therapy

靶向蛋白降解在神经退行性疾病治疗中的进展与挑战

Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation

CRL2ZYG11B E3连接酶的非抑制性配体适体的识别以实现靶向蛋白质降解

Targeted protein degradation: Emerging concepts and protein state-specific targeting principles

蛋白质降解的靶向调控：新兴概念及面向蛋白质特性的靶向原则

Targeted protein degradation through light-activated E3 ligase recruitment

光激活E3连接酶募集促目标蛋白降解

可控的多价LYTACs增强目标蛋白质降解翻译改进