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Trends in pharmacological sciences. 2023 Nov;44(11):758-761. doi: 10.1016/j.tips.2023.09.001 Q119.92025

Harnessing UBR5 for targeted protein degradation of key transcriptional regulators

利用UBR5实现关键转录调节因子的靶向蛋白降解 翻译改进

Asad M Taherbhoy  1, Danette L Daniels  2

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作者单位

  • 1 Foghorn Therapeutics, 500 Technology Square Suite 700, Cambridge, MA 02139, USA.
  • 2 Foghorn Therapeutics, 500 Technology Square Suite 700, Cambridge, MA 02139, USA. Electronic address: ddaniels@foghorntx.com.

    • DOI: 10.1016/j.tips.2023.09.001 PMID: 37770316

    摘要 Ai翻译

    Targeted protein degradation (TPD) has opened the door for drugging transcriptional regulators, yet the number of proteins targeted and E3 ligases utilized remain limited. Here, we highlight UBR5 and propose multiple strategies by which this E3 ligase could be modulated to drive degradation of key transcriptional targets implicated in disease.

    Keywords: HECT E3 ligase; PROTACs; molecular glue; nuclear receptors; transcription factors; ubiquitination.

    Keywords：targeted protein degradation

    关键词：靶向蛋白质降解; 关键转录调节因子UBR5

    Copyright © Trends in pharmacological sciences. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Trends in pharmacological sciences

    缩写：TRENDS PHARMACOL SCI

    ISSN：0165-6147

    e-ISSN：1873-3735

    IF/分区：19.9/Q1

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    Harnessing UBR5 for targeted protein degradation of key transcriptional regulators