Foods (Basel, Switzerland). 2024 Jul 16;13(14):2227. doi: 10.3390/foods13142227 Q15.12025

Comprehensive Amelioration of Metabolic Dysfunction through Administration of Lactiplantibacillus plantarum APsulloc 331261 (GTB1™) in High-Fat-Diet-Fed Mice

植生肠安菌株APsulloc 331261(GTB1™)改善高脂饮食喂养小鼠代谢紊乱的综合评价研究翻译改进

Bobae Kim^{1 2}, Yuri Lee^{1 2}, Chungho Lee¹, Eun Sung Jung³, Hyeji Kang^{1 4}, Wilhelm H Holzapfel^{1 2}

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¹ Basic Research Center, HEM Pharma Inc., Pohang 37554, Republic of Korea.

² Department of Advanced Convergence, Handong Global University, Pohang 37554, Republic of Korea.

³ Multi-Omics Center, HEM Pharma Inc., Suwon 16229, Republic of Korea.

⁴ Global Green Research Institute, Handong Global University, Pohang 37554, Republic of Korea.

DOI: 10.3390/foods13142227 PMID: 39063311

摘要中英对照阅读

The beneficial effects of probiotics for the improvement of metabolic disorders have been studied intensively; however, these effects are evident in a probiotic strain-specific and disease-specific manner. Thus, it is still essential to evaluate the efficacy of each strain against a target disease. Here, we present an anti-obese and anti-diabetic probiotic strain, Lactiplantibacillus plantarum APsulloc331261 (GTB1™), which was isolated from green tea and ... ...点击完成人机验证后继续浏览

益生菌对改善代谢紊乱的有益效果已被广泛研究；然而，这些效果在益生菌株特异性和疾病特异性方面表现明显。因此，评估每种菌株针对目标疾病的疗效仍然是必要的。在这里，我们介绍了一种抗肥胖和抗糖尿病的益生菌株Lactiplantibacillus plantarum APsulloc331261 (@GTB1™)，该菌株从绿茶中分离出来并之前已经测试过安全性。在高脂肪饮食诱导的肥胖小鼠模型中，@GTB1™ 发挥了多种有益效果，包括显著减少肥胖、葡萄糖耐受不良和血脂异常，这些效果进一步通过循环激素和脂肪因子水平的改善得到支持。通过 @GTB1™ 治疗激活 PPAR/PGC1α 信号通路恢复了脂肪组织中的脂质代谢，这得益于肠道微生物群组成的变化以及短链脂肪酸的产生。我们的研究结果提供了证据，表明 @GTB1™ 是一种潜在的益生菌补充剂候选者，可用于全面改善代谢紊乱。

关键词： Lactobacillus plantarum APsulloc 331261 (@GTB1™)；肠道微生物群调节；代谢功能障碍；肥胖；过氧化物酶体增殖激活受体 (PPARs)；短链脂肪酸 (SCFAs)。

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Comprehensive Amelioration of Metabolic Dysfunction through Administration of Lactiplantibacillus plantarum APsulloc 331261 (GTB1™) in High-Fat-Diet-Fed Mice

植生肠安菌株APsulloc 331261(GTB1™)改善高脂饮食喂养小鼠代谢紊乱的综合评价研究翻译改进

Impact of Oral Administration of Lactiplantibacillus plantarum Strain CNCM I-4459 on Obesity Induced by High-Fat Diet in Mice

口服植物乳杆菌 CNCM I-4459 对高脂饮食诱导的小鼠肥胖的影响

Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice

植物乳杆菌H-87通过调节胆汁酸代谢预防高脂饮食诱导的小鼠肥胖

Lactiplantibacillus plantarum BXM2 Treatment Alleviates Disorders Induced by a High-Fat Diet in Mice by Improving Intestinal Health and Modulating the Gut Microbiota

植物乳杆菌BXM2治疗通过改善肠道健康和调节肠道微生物群来缓解高脂饮食诱导的小鼠代谢紊乱

Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice

Lactiplantibacillus植物杆菌SKO-001对高脂饮食诱导的肥胖小鼠的抗肥胖作用

Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice

APJ介导的β- arrestin信号的丢失可改善小鼠高脂饮食诱导的代谢功能障碍，但不会改变心脏功能

Author Correction: Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

作者更正：重组胰岛素分泌微生物改善高脂饮食喂养啮齿动物的代谢紊乱

Zingerone mitigates metabolic dysfunction and alters pro-opiomelanocortin gene expression in offspring of high-fat diet-fed pregnant wistar rats

姜根醇可以改善高脂饮食喂养的孕大鼠后代出现的新陈代谢功能紊乱，并改变促黑色素细胞激素基因表达

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

分泌肠降糖激素的工程益生菌改善高脂饮食诱导的小鼠代谢紊乱

Comprehensive Amelioration of Metabolic Dysfunction through Administration of Lactiplantibacillus plantarum APsulloc 331261 (GTB1™) in High-Fat-Diet-Fed Mice

植生肠安菌株APsulloc 331261(GTB1™)改善高脂饮食喂养小鼠代谢紊乱的综合评价研究 翻译改进

Impact of Oral Administration of Lactiplantibacillus plantarum Strain CNCM I-4459 on Obesity Induced by High-Fat Diet in Mice

口服植物乳杆菌 CNCM I-4459 对高脂饮食诱导的小鼠肥胖的影响

Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice

植物乳杆菌H-87通过调节胆汁酸代谢预防高脂饮食诱导的小鼠肥胖

Lactiplantibacillus plantarum BXM2 Treatment Alleviates Disorders Induced by a High-Fat Diet in Mice by Improving Intestinal Health and Modulating the Gut Microbiota

植物乳杆菌BXM2治疗通过改善肠道健康和调节肠道微生物群来缓解高脂饮食诱导的小鼠代谢紊乱

Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice

Lactiplantibacillus植物杆菌SKO-001对高脂饮食诱导的肥胖小鼠的抗肥胖作用

Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice

APJ介导的β- arrestin信号的丢失可改善小鼠高脂饮食诱导的代谢功能障碍，但不会改变心脏功能

Author Correction: Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

作者更正：重组胰岛素分泌微生物改善高脂饮食喂养啮齿动物的代谢紊乱

Zingerone mitigates metabolic dysfunction and alters pro-opiomelanocortin gene expression in offspring of high-fat diet-fed pregnant wistar rats

姜根醇可以改善高脂饮食喂养的孕大鼠后代出现的新陈代谢功能紊乱，并改变促黑色素细胞激素基因表达

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

分泌肠降糖激素的工程益生菌改善高脂饮食诱导的小鼠代谢紊乱

植生肠安菌株APsulloc 331261(GTB1™)改善高脂饮食喂养小鼠代谢紊乱的综合评价研究翻译改进