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Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023 Dec 1;64(12):1880-1888. doi: 10.2967/jnumed.123.265715 Q19.12025

First-in-Humans PET Imaging of KRASG12C Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [18F]PFPMD

用于非小细胞肺癌和结直肠癌患者的携带KRASG12C突变状态的[18F]PFPMD首次人体PET成像研究 翻译改进

Xiang Li  1, Jiajun Ye  1, Jingyi Wang  1, Zhiyong Quan  1, Guiyu Li  1, Wenhui Ma  1, Mingru Zhang  1, Weidong Yang  1, Junling Wang  1, Taoqi Ma  1, Fei Kang  2, Jing Wang  2

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作者单位

  • 1 Department of Nuclear Medicine and State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • 2 Department of Nuclear Medicine and State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Xijing Hospital, Fourth Military Medical University, Xi'an, China 13909245902@163.com fmmukf@qq.com.
  • DOI: 10.2967/jnumed.123.265715 PMID: 37827842

    摘要 Ai翻译

    Kirsten rat sarcoma (KRAS) mutations are an important marker for tumor-targeted therapy. In this study, we sought to develop a KRASG12C oncoprotein-targeted PET tracer and to evaluate its translational potential for noninvasive imaging of the KRASG12C mutation in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) patients. Methods: [18F]PFPMD was synthesized on the basis of AMG510 (sotorasib) by attaching a polyethylene glycol chain to the quin... ...点击完成人机验证后继续浏览
    Copyright © Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Journal of nuclear medicine

    缩写:J NUCL MED

    ISSN:0161-5505

    e-ISSN:1535-5667

    IF/分区:9.1/Q1

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    First-in-Humans PET Imaging of KRASG12C Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [18F]PFPMD