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Lung cancer (Amsterdam, Netherlands). 2020 Aug:146:310-317. doi: 10.1016/j.lungcan.2020.06.030 Q14.42025

Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer

携带KRAS G12C突变的非小细胞肺癌的真实世界预后 翻译改进

Wanyuan Cui  1, Fanny Franchini  2, Marliese Alexander  3, Ann Officer  4, Hui-Li Wong  5, Maarten IJzerman  6, Jayesh Desai  7, Benjamin J Solomon  7

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作者单位

  • 1 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia. Electronic address: Wanda.cui@petermac.org.
  • 2 University of Melbourne, Centre for Health Policy and Centre for Cancer Research, Melbourne, VIC, 3000, Australia.
  • 3 Pharmacy Department, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia.
  • 4 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
  • 5 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.
  • 6 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Pharmacy Department, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
  • 7 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia.

    • DOI: 10.1016/j.lungcan.2020.06.030 PMID: 32619782

    摘要 Ai翻译

    Background: KRAS mutations are found in 20-30 % of non-small cell lung cancers (NSCLC) and were traditionally considered undruggable. KRASG12C mutation confers sensitivity to KRASG12C covalent inhibitors, however its prognostic impact remains unclear. This study assesses the frequency, clinical features, prevalence of brain metastases and outcomes in KRASG12C NSCLC in a real-world setting. ... ...点击完成人机验证后继续浏览
    Copyright © Lung cancer (Amsterdam, Netherlands). 中文内容为AI机器翻译，仅供参考！

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    期刊名：Lung cancer

    缩写：LUNG CANCER

    ISSN：0169-5002

    e-ISSN：1872-8332

    IF/分区：4.4/Q1

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    Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer