Beyond Radiochemistry: An Integrated Translational Blueprint for the Next Generation of Radionuclide Ligand Conjugates [0.03%]
超越放射化学：下一代核素配体缀合物的综合转化蓝图
Chen Fu,Xiaoyan Li
Chen Fu
Radionuclide ligand conjugates (RLCs) have emerged as a powerful therapeutic and theranostic platform in oncology, with clinical validation achieved in prostate-specific membrane antigen- and somatostatin receptor-directed settings. Yet the...
68Ga-HER2 PET/CT for Predicting Pathologic Response to Neoadjuvant Therapy at Early Treatment and Preoperative Stages in HER2-Positive Breast Cancer: A Prospective Study [0.03%]
68镓-HER2 PET/CT预测新辅助治疗早期阶段和术前HER2阳性乳腺癌病理反应的前瞻性研究
Sinuo Gao,Zhaoqi Zhang,Chao Shi et al.
Sinuo Gao et al.
This study aimed to evaluate the predictive performance of 68Ga-HER2 PET/CT in assessing pathologic response to neoadjuvant therapy (NAT) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Methods: In total, 45 patie...
Patient Survival and Its Relation to Tumor Absorbed Dose in [177Lu]Lu-DOTATATE Therapy of Neuroendocrine Tumors [0.03%]
镥-177DOTATATE治疗神经内分泌肿瘤的患者生存率及其与肿瘤吸收剂量的关系
Carl Fredrik Warfvinge,Selma Curkic Kapidzic,Johan Gustafsson et al.
Carl Fredrik Warfvinge et al.
[177Lu]Lu-DOTATATE is an established treatment for metastasized neuroendocrine tumors (NETs). It is postulated that a higher tumor absorbed dose (AD) improves clinical efficacy. The aim of this study was to assess the average AD of the enti...
Normal Tissue Dosimetry of Intraperitoneal 224Ra Microparticle Therapy: Data from First-in-Human Studies in Patients with Peritoneal Metastases [0.03%]
基于人的第一次腹膜转移瘤224Ra微粒治疗的正常组织剂量学数据研究
Simen Rykkje Grønningsæter,Johan Blakkisrud,Monika Kvassheim et al.
Simen Rykkje Grønningsæter et al.
Two early-phase clinical studies evaluated α-emitting 224Ra adsorbed to calcium carbonate microparticles ([224Ra]CaCO3-MP). Patients with peritoneal metastases from ovarian or colorectal cancer underwent complete cytoreductive surgery 2 da...
Real-World Outcomes of [177Lu]Lu-PSMA-617 in the French Early-Access Program for Patients with Metastatic Castration-Resistant Prostate Cancer [0.03%]
[177Lu]Lu-PSMA-617治疗转移性去势抵抗性前列腺癌患者的真实世界结果：法国早期准入项目的经验
Clément Bailly,Lavinia Vija,François Somme et al.
Clément Bailly et al.
Metastatic castration-resistant prostate cancer (mCRPC) remains challenging to treat, especially after failure of standard therapies, such as androgen receptor pathway inhibitors and taxane-based chemotherapy. Radiopharmaceutical therapy wi...
Concordance Between [18F]Flortaucipir PET Visual Reads and CenTauR-Based Quantification [0.03%]
[18F]Flortaucipir PET视觉读数与CenTauR-based定量的一致性
Stamatia Karagianni,Alexis Moscoso,Sheelakumari Raghavan et al.
Stamatia Karagianni et al.
Tau PET imaging with [18F]flortaucipir allows for the visualization and mapping of aggregated tau deposits, a key neuropathologic feature of Alzheimer disease (AD). A visual interpretation method for [18F]flortaucipir was approved by the Fo...
Theranostic Approach Using Radioiodinated Trimethoprim Targeting E. coli Dihydrofolate Reductase in Engineered Cells [0.03%]
一种用于工程细胞的放射性碘标记三甲氧苄氨嘧啶靶向大肠杆菌二氢叶酸还原酶的诊疗方法
Nitika Sharma,Swarbhanu Sarkar,Jean M Etersque et al.
Nitika Sharma et al.
Radiopharmaceutical therapy (RPT) has re-emerged as a potent approach for targeting tumors, particularly for the treatment of neuroendocrine tumors and prostate cancer expressing the somatostatin and prostate-specific membrane antigen recep...
Hematologic Consequences of Radiopharmaceutical Therapy: From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms [0.03%]
放射药物治疗的血液学后果：从克隆性造血到治疗相关骨髓肿瘤
Wallace Klein Schwengber,Jeremiah Sanders,Aubrey Pinteric et al.
Wallace Klein Schwengber et al.
Radiopharmaceutical therapy (RPT) uses radionuclides linked to targeting ligands to bind tumor-associated receptors or antigens and deliver ionizing radiation to malignant cells. Approved agents include [177Lu]Lu-DOTATATE for gastroenteropa...
Elena Becker-Barroso Talks with Henry Barthel About The Lancet Neurology [0.03%]
埃伦娜·贝克尔-巴罗索与亨利·巴塞尔谈《柳叶刀-神经病学》
Elena Becker-Barroso,Henryk Barthel
Elena Becker-Barroso