Jiawen Xie,Hayam Hamdy,Eyad Elkord
Jiawen Xie
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; however, a significant proportion of patients fail to respond, in part due to persistent immunosuppression mediated by regulatory T cells (Tregs). Previous efforts to targ...
Eva Berenger,Alice Maestri,Daniel R Vaz et al.
Eva Berenger et al.
Chaperone-mediated autophagy (CMA) is a selective lysosomal protein degradation pathway that regulates proteostasis, metabolism, and stress adaptation. Genetic- and disease-model studies show that altered CMA activity contributes to diverse...
Wenhui Wang,Yang Liu,Gaofei Wei
Wenhui Wang
Covalent drugs display rich in vivo reactivity landscapes that remain largely unmapped. A recent Cell study by Pang et al. introduces vCATCH (volumetric clearing-assisted tissue click chemistry), a chemistry-driven platform combining clicka...
Topical difamilast for the treatment of mild-to-moderate atopic dermatitis [0.03%]
用于轻中度特应性皮炎治疗的外用difamilast(df4825)
Md Asaduzzaman Rakib,Jianxiong Jiang,Ying Yu
Md Asaduzzaman Rakib
Difamilast (also known as OPA-15406 or MM36) is a non-steroidal, highly selective inhibitor of phosphodiesterase 4 (PDE4). Its chemical name is N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide. Th...
Mouxin Huang,He Liu,Jinwei Zhu et al.
Mouxin Huang et al.
Biomolecular condensates formed through liquid-liquid phase separation (LLPS) are widely regarded as a fundamental mode of cellular organization. Many intractable diseases, including cancer and neurodegenerative disorders, are increasingly ...
Programmable CAR immunotherapies for neurodegenerative proteinopathies [0.03%]
可编程的CAR免疫疗法治疗神经退行性蛋白病
Giulia Pesce,Marc Estivill-Alonso,Salvador Ventura
Giulia Pesce
Abnormal protein aggregation and a dysregulated neuroimmune environment are defining features of many neurodegenerative disorders. In Alzheimer's disease, systemic monoclonal antibodies against amyloid-β provide proof of principle that imm...
Wei-Lin Jin,Ming-Zhu Jin
Wei-Lin Jin
How tumors manipulate neural circuits to evade immunity is unclear. In a recent study, Wei et al. reveal, in lung adenocarcinoma, a vagal sensory-brain stem sympathetic circuit that suppresses macrophages and CD8+ T cells via β2-adrenergic...
Minjeong Ko,Jiho You,Eunwoo Cho et al.
Minjeong Ko et al.
Organelle membrane contact sites (MCSs) regulate calcium exchange, lipid transfer, metabolism, and cellular stress responses. Dysregulation of MCSs contributes to diverse diseases, yet pharmacological strategies that directly modulate conta...
Kwang-Su Park,Taeg Kyu Kwon
Kwang-Su Park
Induced-proximity dephosphorylation is a strategy that recruits phosphatases to target proteins for selective and reversible phosphate removal. This strategy enables context-dependent reprogramming of pathological phosphorylation with impro...
Pharmacological strategies targeting hepatocyte-mediated crosstalk in liver fibrosis [0.03%]
针对肝纤维化中肝细胞介导的串扰的药理学策略
Yue Zhang,Meng-Guang Wei,Xin-Yue Zhou et al.
Yue Zhang et al.
Liver fibrosis is a common pathological outcome of chronic liver injury. Many therapeutic agents show limited clinical efficacy or significant adverse effects due to the complex pathogenesis of liver fibrosis. This challenge underscores the...