Mengqin Guo,Wenhao Wang,Zhengwei Huang
Mengqin Guo
Oncolytic viruses hold immense therapeutic promise but face formidable systemic delivery barriers. A new study by Xu et al. engineered immunoglobulin E-sensitized mast cells to selectively ferry these viruses into tumors. Excitingly, antige...
Tau-targeting pharmacological strategies in neurodegenerative disease [0.03%]
靶向tau蛋白的小分子药物在神经退行性疾病治疗中的应用
Hanyuan Zheng,Jie Zheng
Hanyuan Zheng
Pathological tau accumulation underlies a spectrum of neurodegenerative diseases collectively known as tauopathies. Although reducing tau remains the prevailing therapeutic strategy, indiscriminate tau reduction may compromise physiological...
Sequential EGFR inhibition sensitizes glioblastoma to temozolomide [0.03%]
表皮生长因子受体的顺序抑制可增强胶质母细胞瘤对替莫唑胺的敏感性
Xiaozhou Yu,Runxin Wu,Shi-Yuan Cheng
Xiaozhou Yu
Glioblastoma (GBM) remains a devastating disease for which standard temozolomide chemotherapy is limited by O6-methylguanine-DNA methyltransferase (MGMT)-mediated DNA damage repair. By targeting epidermal growth factor receptor (EGFR), a ma...
Sex-sensitive serotonergic signaling in psychedelic pharmacology [0.03%]
psychedelics药理学中的性别敏感血清素信号转导
Sofia Nasini,Benedetta Barzon,Antonino Casile et al.
Sofia Nasini et al.
Classic serotonergic psychedelics act primarily via 5-HT2A receptor agonism, yet their therapeutic effects and biological responses are heterogeneous. Biological sex remains an underexamined source of this variability because many clinical ...
Amyloidogenic amylin signaling links diabetes to dementia pathogenesis [0.03%]
淀粉样蛋白原纤维的淀粉肽信号连接糖尿病与痴呆症病理学
Florin Despa,Tammaryn Lashley
Florin Despa
Recent studies identify amyloidogenic human amylin, secreted by the pancreas, as a potential link between type-2 diabetes and Alzheimer's disease. Evidence suggests that pathogenic amylin signaling impairs cerebral bioenergetics, promoting ...
Rasaq Akinsola,Jing Xian,James Turkson
Rasaq Akinsola
Pharmacological targeting of Signal Transducer and Activator of Transcription 3 (STAT3) in cancer has demonstrable antitumor efficacy. However, suitably potent, efficacious, and safe STAT3 inhibitors are scarce, and only a handful have ente...
Ramesha Hanumanthappa,Nandakumar Dalavaikodihalli Nanjaiah,Sudhir H Ranganath
Ramesha Hanumanthappa
The clinical translation of stimulator of interferon genes (STING)agonist-based cancer immunotherapy is limited by uncontrolled and sustained STING activation, which leads to immune exhaustion and systemic toxicity. In this forum, we critic...
Forever chemicals, the microbiome, and brain health: towards therapeutics [0.03%]
永恒化学物质、微生物组与脑健康：迈向治疗对策
Dhirendra Pratap Singh,Eileen Ryan,Gerard Clarke et al.
Dhirendra Pratap Singh et al.
Per- and polyfluoroalkyl substances (PFAS) are persistent xenobiotics linked to neurodevelopmental, neurodegenerative, and neurological disorders. PFAS-induced gut microbiota remodelling may disrupt gut-brain signalling, thereby affecting b...
Endothelial insulin-like growth factor 1 receptor-targeted vessel normalization potentiates neuroendocrine cancer immunotherapy [0.03%]
内皮胰岛素样生长因子1受体靶向血管正常化增强神经内分泌癌免疫治疗
Weici Laurence Liu,Wenjun Mao
Weici Laurence Liu
Angiogenesis fuels cancer progression, yet its immunomodulatory role in neuroendocrine malignancies remains poorly understood. Recently, Wang et al. identified a blood-brain barrier-like vascular gate that mediates immune exclusion and immu...
Bethan Cole,Tarek Mohamed Abd El-Aziz,Hyemi Eo et al.
Bethan Cole et al.