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The Journal of biological chemistry. 2023 Aug;299(8):105014. doi: 10.1016/j.jbc.2023.105014 Q23.92025

Heme binding to the SARS-CoV-2 spike glycoprotein

血红素与SARS-CoV-2刺突糖蛋白的结合 翻译改进

Samuel L Freeman  1, A Sofia F Oliveira  1, Andrea E Gallio  1, Annachiara Rosa  2, Maria K Simitakou  2, Christopher J Arthur  1, Adrian J Mulholland  1, Peter Cherepanov  3, Emma L Raven  4

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作者单位

  • 1 School of Chemistry, Cantock's Close, University of Bristol, Bristol, United Kingdom.
  • 2 Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.
  • 3 Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom; Department of Infectious Disease, St-Mary's Campus, Imperial College London, United Kingdom. Electronic address: Peter.Cherepanov@crick.ac.uk.
  • 4 School of Chemistry, Cantock's Close, University of Bristol, Bristol, United Kingdom. Electronic address: emma.raven@bristol.ac.uk.

    • DOI: 10.1016/j.jbc.2023.105014 PMID: 37414149

    摘要 Ai翻译

    The target for humoral immunity, SARS-CoV-2 spike glycoprotein, has become the focus of vaccine research and development. Previous work demonstrated that the N-terminal domain (NTD) of SARS-CoV-2 spike binds biliverdin-a product of heme catabolism-causing a strong allosteric effect on the activity of a subset of neutralizing antibodies. Herein, we show that the spike glycoprotein is also able to bind heme (KD = 0.5 ± 0.2 μM). Molecular modeling indicated... ...点击完成人机验证后继续浏览
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    期刊名：Journal of biological chemistry

    缩写：J BIOL CHEM

    ISSN：N/A

    e-ISSN：1083-351X

    IF/分区：3.9/Q2

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    Heme binding to the SARS-CoV-2 spike glycoprotein