Atropo-enantioselective biaryl coupling through C-H bond functionalization is an emerging technology allowing direct construction of axially chiral molecules. This approach is largely limited to electrophilic coupling partners. We report a highly atropo-enantioselective C-H arylation of tetralone derivatives paired with aryl boronic esters as nucleophilic components. The transformation is catalyzed by chiral cyclopentadienyl (Cpx ) iridium(III) complexes and enabled by oxidatively enhanced reductive elimination from high-valent cyclometalated Ir-species.
Keywords: C-H functionalization; asymmetric catalysis; atropselectivity; chiral cyclopentadienyl; iridium.
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
