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Comment The Journal of investigative dermatology. 2019 Mar;139(3):514-517. doi: 10.1016/j.jid.2018.11.026 Q15.72025

Making New Connections-Chromosome Conformation Capture for Identification of Disease-Associated Target Genes

建立新的联系——染色体构象捕获在疾病相关靶基因鉴定中的应用 翻译改进

Matthew T Patrick  1, Lam C Tsoi  2, Johann E Gudjonsson  3

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  • 1 Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 2 Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • 3 Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: johanng@med.umich.edu.

    • DOI: 10.1016/j.jid.2018.11.026 PMID: 30797317

    摘要 Ai翻译

    Most susceptibility loci for complex dermatologic diseases fall within non-coding regions, making assignment of function difficult. Chromosome conformation capture addresses this problem by using the spatial organization of chromatin to identify the genes these loci interact with, often across long distances. Furthermore, as gene regulation is tissue-/cell-dependent, studying relevant cell populations is critical to reveal the molecular mechanisms involved.

    Keywords：disease-associated genes

    关键词：染色体构象捕获; 疾病相关基因

    Copyright © The Journal of investigative dermatology. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Journal of investigative dermatology

    缩写：J INVEST DERMATOL

    ISSN：0022-202X

    e-ISSN：1523-1747

    IF/分区：5.7/Q1

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    Making New Connections-Chromosome Conformation Capture for Identification of Disease-Associated Target Genes