Dementia of the Alzheimer type (AD) is the leading cause of dementias for the elders. It is a progressively neurodegenerative disorder characterized by global cognitive decline. While most of the rare early-onset AD can be explained by mutations in APP gene and presenilin genes,the genetic etiology of the more common late-onset AD is only partly explained by the APOE-epsilon4 genotype. But the APOE-epsilon4 allele is neither necessary nor sufficient to cause disease and it can only account for less than one-half of the genetic variance of AD. Thus, more genes involved in AD are our special attention.
Yi chuan = Hereditas. 2003 Jul;25(4):445-9. 0.02025
[Associated genes for dementia of the Alzheimer type]
与阿尔茨海默病型痴呆相关基因 翻译改进
Article in Chinese
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PMID: 15639906
摘要 Ai翻译
Keywords：alzheimer disease; associated genes
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