Generative skin-tone augmentation reduces Fitzpatrick skin type disparities in skin tumor classification [0.03%]
生成肤色增强减少Fitzpatrick皮肤类型在皮肤肿瘤分类中的差异性
Gyeonghoon Kim,Doa Kim,Jiwon Hwang et al.
Gyeonghoon Kim et al.
Generative skin-tone augmentation reduces Fitzpatrick skin type disparities in skin tumor classification [0.03%]
生成肤色增强减少Fitzpatrick皮肤类型在皮肤肿瘤分类中的差异
Gyeonghoon Kim,Doa Kim,Jiwon Hwang et al.
Gyeonghoon Kim et al.
Activatable photoimmunotherapy enables spatiotemporal depletion of pathogenic cells in immune-driven disease and cancer [0.03%]
可激活的光免疫疗法可在时间和空间上清除自身免疫病和癌症中的致病细胞
Eric M Kercher,Amissi Sadiki,Shanshan Liu et al.
Eric M Kercher et al.
Photoimmunotherapy (PIT) combines antibody specificity with light-activated cytotoxicity to enable precise, spatially and temporally confined cell depletion. However, the leading clinical-stage PIT agent, cetuximab-IR700, can induce inflamm...
Genomic and spatial transcriptomics identify fibroblast-associated microenvironment in early mycosis fungoides progression [0.03%]
基因组和空间转录组学识别出纤维母细胞相关微环境促进早期蕈样霉菌病进展
Myoung Eun Choi,Ji Hun Choi,Hwajeong Shin et al.
Myoung Eun Choi et al.
Early-stage mycosis fungoides (MF) manifests as patch or plaque lesions, and cancer-associated fibroblasts (CAFs) may promote tumorigenesis and Th2-skewed microenvironment. This study aimed to investigate genomic and transcriptomic changes ...
Sensory neurons shape γδ T cell effector programs to control psoriasiform inflammation [0.03%]
感觉神经元塑形γδT细胞效应程序以控制银屑病样炎症反应
Juan M Inclan-Rico,Camila M Napuri,Adriana Stephenson et al.
Juan M Inclan-Rico et al.
Psoriasis is a chronic autoimmune skin disorder marked by IL-17-producing γδ T cell (γδT17) and pruritus, but immunoregulatory roles of itch-inducing neurons in this context remain unclear. This study addressed whether non-peptidergic (...
Reframing hidradenitis suppurativa through basic and translational science [0.03%]
通过基础和转化科学研究重新定义汗腺炎
Michal Kidacki,Anna Eisenstein,Tammy Gonzalez et al.
Michal Kidacki et al.
Mapping the global work-related impact of immune-mediated inflammatory skin diseases: a systematic review [0.03%]
基于免疫介导的炎症性皮肤病工作相关影响的系统评价
Fanny C Kpenou,Ju Hee Han,Marc Fadel et al.
Fanny C Kpenou et al.
Immune-mediated inflammatory diseases (IMIDs) of the skin can significantly affect individuals' work functioning and pose societal challenges. This systematic review examined the burden of common skin IMIDs (alopecia areata, atopic dermatit...
Divergent roles of TRPV1 and neuropeptides in mouse model of atopic dermatitis [0.03%]
瞬时受体电位香草素1通道和神经肽在小鼠过敏性皮炎模型中发挥不同作用
Joshua James Wheeler,Santosh Kumar Mishra
Joshua James Wheeler
Lipase GehA functions as a positive-feedback amplifier of Cutibacterium acnes-sebum interactions in acne pathogenesis [0.03%]
丙酸痤疮丙烷杆菌脂肪酶GehA在痤疮发病机制中作为皮脂-病原菌相互作用的正反馈放大器的功能
Yangfan Lai,Mengjie Fan,Xiaoyao Fan et al.
Yangfan Lai et al.
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit in which Cutibacterium acnes interacts dynamically with the sebum microenvironment. The bacterial factors that sense and remodel this environment remain poorly chara...
Disease context dictates the cellular targets of IL-17 in inflammatory skin disease [0.03%]
疾病背景决定了IL-17在炎症性皮肤病中的细胞靶点
Kellen J Cavagnero,Fengwu Li,Haley Jo et al.
Kellen J Cavagnero et al.
IL-17 and TNF blockade effectively treats hidradenitis suppurativa and psoriasis, yet the relative importance of the different cell types that respond to IL-17 and TNF remains unresolved. Keratinocytes are viewed as the dominant effector ce...