Direct sensitizing and activating effects of interleukin 31 are restricted to a single, functionally and transcriptionally classified porcine DRG neuron subtype [0.03%]
白细胞介素31对功能分类和转录分类的单一种猪背根神经节神经元亚型具有直接致敏和激活作用
Zeinab Abbasi,Marc Behrendt,Sabrina da Silva Soares et al.
Zeinab Abbasi et al.
Interleukin-31 (IL-31) drives chronic pruritus in patients with dermatological and even certain systemic diseases. However, fast-onset anti-pruritic effects of blocking IL-31 receptors, for instance with nemolizumab in atopic dermatitis pat...
Cutibacterium acnes induce T cell extracellular traps with distinct proteome programs [0.03%]
Cutibacterium acnes诱导具有不同蛋白组计划的T细胞胞外陷阱
Thao Tam To,Min Deng,Priscila R Andrade et al.
Thao Tam To et al.
Cutibacterium acnes (C. acnes) is a common skin commensal associated in acne pathogenesis. Here, we investigated whether acne-associated (HL043PA1, CA) and healthy skin-associated (HL110PA3, CH) C. acnes strains differentially induce extrac...
Madison Weber,Amanda Ackermann,Meng-Yen Li et al.
Madison Weber et al.
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with a poorly understood cell of origin and initiation process. Most MCC tumors feature monoclonal integration of Merkel cell polyomavirus (MCPyV) DNA, which expr...
Topical 5-fluorouracil versus photodynamic therapy: differential impact on epidermal clonal mutations in early UV-induced skin carcinogenesis [0.03%]
外用氟尿嘧啶与光动力疗法对早期紫外线诱导皮肤癌前病变表皮克隆突变的不同影响
Gyorgy Paragh,Mitsuko Murakami,Megan E Fitzgerald et al.
Gyorgy Paragh et al.
Éva Ádám,Anita Hajdu,Hodgson Kirsty et al.
Éva Ádám et al.
Spatial Transcriptomics Identifies Cytotoxic and Fibrotic Immune-Stromal Niches in Morphea and Eosinophilic Fasciitis [0.03%]
空间转录组学识别出硬化病和嗜酸细胞性肌炎中的细胞毒性和纤维化免疫-基质生态位
William J Crisler,Kseniia S Anufrieva,Maureen Whittelsey et al.
William J Crisler et al.
Agathe Hercent,Dimitri Tchernitchko
Agathe Hercent
Cutaneous dysbiosis in inherited ichthyoses/epidermal differentiation disorders: a prospective case-control study [0.03%]
针对遗传性鱼鳞病/角化异常的皮肤病原菌失衡：一项前瞻性病例对照研究
Axel Künstner,Ahmed Abdelhamid,Federica Casetti et al.
Axel Künstner et al.
An ITGB4 variant modifies the severity of ITGA3-associated interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa (ILNEB) [0.03%]
ITGB4变异可修改ITGA3相关性间质性肺病、肾病综合征和大疱性表皮松解症（ILNEB）的严重程度
Lubna Gazi Khair,Ofer Sarig,Rawaa Fayez Ishtewy et al.
Lubna Gazi Khair et al.
Biallelic ITGA3 variants cause a rare subtype of junctional epidermolysis bullosa named interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa (ILNEB). ILNEB is characterized by extensive clinical heterogeneity, suggesting...
Selective blockade of γc pathway ameliorates alopecia areata in a humanized murine model [0.03%]
人源化小鼠模型中选择性阻断γc信号通路改善斑秃病症
Wai Chung Wu,Muthu Iswarya Gandhi Sethuraman,Tak Keung Tong et al.
Wai Chung Wu et al.
Alopecia areata (AA) is a chronic autoimmune disease characterized by sudden patchy hair loss and persistent inflammation. To date, only JAK inhibitors have been approved for AA treatment, but FDA-issued black box warnings highlight the nee...