Segmental vitiligo: A distinct entity with unique pathogenesis and clinical implications [0.03%]
节段型白癜风：具有独特的发病机制和临床意义的独立疾病实体
Naiting Shen,Qinyi Fang,Yijie Xuan et al.
Naiting Shen et al.
Segmental vitiligo (SV) is characterized by unilateral depigmentation, frequent leukotrichia, early stabilization, and unique pathomechanisms that differentiate it from nonsegmental vitiligo. This review systematically examines the epidemio...
Pre-eradication fecal Helicobacter pylori antigen levels as a predictive marker for skin eruption during eradication therapy [0.03%]
根除治疗前幽门螺杆菌粪便抗原检测水平对预测根除治疗过程中皮肤不良反应的意义
Toru Kawai,Ryota Hayashi,Akito Hasegawa et al.
Toru Kawai et al.
Proteomics Reveals Altered Lipid Biosynthesis and Keratin Hyperphosphorylation in Pachyonychia Congenita [0.03%]
蛋白质组学揭示了先天性厚甲症中脂质生物合成改变和角蛋白过度磷酸化
Sara Ceccacci,Kevin Roger,Lucile Marchal et al.
Sara Ceccacci et al.
Pachyonychia congenita (PC) is a rare and painful skin disorder caused by dominant pathogenic variants in keratin genes (KRT6A/KRT6B/KRT6C/KRT16/KRT17), with no effective treatment. We developed a scalable, in-depth and miniaturized MS-base...
Botulinum Neurotoxin Type A1 Alleviates Bleomycin-induced Skin Fibrosis by Inhibiting PI3K-Akt Pathway and Associated Cell Cycle and Proliferation [0.03%]
肉毒杆菌毒素A1通过抑制PI3K-Akt途径及其相关细胞周期和增殖缓解血红蛋白诱导的皮肤纤维化
Fangzhou Xie,Yun Xie,Jia Liu
Fangzhou Xie
Localized scleroderma (LoS) is a chronic dermal disease with fibrotic skin and subcutaneous tissues. Due to the largely undefined pathogenesis, there is no specific medical treatment for LoS. Recent investigator-initiated tests have reveale...
Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo [0.03%]
基于细胞治疗斑秃：人源Vδ2+Foxp3+γδTreg细胞体外和体内恢复斑秃免疫豁免并促进头发生长
Aviad Keren,Nyra Goldstein,Marta Bertolini et al.
Aviad Keren et al.
While regulatory T cells (Tregs) control autoimmune diseases (AID), the role of evolutionarily older Foxp3+ γδTregs is much less understood. We noted that both lesional and non-lesional skin of patients with alopecia areata (AA), one of t...
Nested case-control and case-cohort: Efficient study designs to develop biomarker-based prediction models for rare outcomes [0.03%]
巢式病例对照和队列病例设计：开发罕见结果的生物标志物预测模型的有效研究设计
Barbara Rentroia-Pacheco,Olivia F M Steijlen,Domenico Bellomo et al.
Barbara Rentroia-Pacheco et al.
Prediction models that accurately predict patient prognosis and treatment response enable the development of personalized treatment plans in dermatology as well as outside dermatology. This can improve patient care and reduce the use of ine...
Regional spatial transcriptomics and immune cell profiling in folliculotropic mycosis fungoides [0.03%]
毛囊性蕈样霉菌病的空间转录组学和免疫细胞图谱
Kang Su Kim,Myoung Eun Choi,Mina Song et al.
Kang Su Kim et al.
The Birt-Hogg-Dubé syndrome gene folliculin (FLCN), operates as a negative regulator of human hair follicle growth ex vivo [0.03%]
Birt-Hogg-Dubé综合征基因多囊发瘤素（FLCN）可离体抑制人毛囊生长
William Fostier,Kinga Linowiecka,Sabrina Martin et al.
William Fostier et al.
Sandrine Dubrac,Daniel Combarros,Attila Oláh et al.
Sandrine Dubrac et al.