首页 文献索引 SCI期刊 AI助手
首页 正文

mBio. 2018 Dec 18;9(6):e01606-18. doi: 10.1128/mBio.01606-18 Q14.72025

CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII

铜绿假单胞菌分泌的特异性糖蛋白结合的ADAM金属蛋白酶CPAA失活凝血因子FXII 翻译改进

Ursula Waack  1, Mark Warnock  2, Andrew Yee  3, Zachary Huttinger  3, Sara Smith  1, Ayush Kumar  4, Alban Deroux  5, David Ginsburg  3  6  7  8  9, Harry L T Mobley  1, Daniel A Lawrence  2, Maria Sandkvist  10

作者单位 +展开

作者单位

  • 1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 2 Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 3 Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • 4 Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
  • 5 Grenoble Alpes University Hospital, Grenoble, France.
  • 6 Howard Hughes Medical Institute, Ann Arbor, Michigan, USA.
  • 7 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 8 Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 9 Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • 10 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA mariasan@umich.edu.

    • DOI: 10.1128/mBio.01606-18 PMID: 30563903

    摘要 Ai翻译

    Antibiotic-resistant Acinetobacter baumannii is increasingly recognized as a cause of difficult-to-treat nosocomial infections, including pneumonia, wound infections, and bacteremia. Previous studies have demonstrated that the metalloprotease CpaA contributes to virulence and prolongs clotting time when added to human plasma as measured by the activated partial thromboplastin time (aPTT) assay. Here, we show that CpaA interferes with the intrinsic coagulat... ...点击完成人机验证后继续浏览
    Copyright © mBio. 中文内容为AI机器翻译，仅供参考！

    相关内容

    期刊名：Mbio

    缩写：MBIO

    ISSN：N/A

    e-ISSN：2150-7511

    IF/分区：4.7/Q1

    文章目录 更多期刊信息

    全文链接
    官方链接
    PMC全文
    引文链接
    复制
    已复制！
    推荐内容
    CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII