Assessing the function of the alternative electron transport chain in the Cryptosporidium parvum mitosome [0.03%]
隐孢子虫类卵囊体中替代电子传递链的功能评估
Silu Deng,Wandy Beatty,L David Sibley
Silu Deng
Cryptosporidium parvum and C. hominis possess a remanent mitochondrion called the mitosome, which lacks DNA, the tricarboxylic acid cycle, a conventional electron transport chain, and ATP synthesis. The mitosome retains ubiquinone and iron-...
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development [0.03%]
金黄色葡萄球菌在肾脓肿发展过程中的Sae活性的时空异质性
Anjali Anil,Rezia Era D Braza,Bessie Liu et al.
Anjali Anil et al.
Virulence factors are required for bacterial pathogens to establish infection; however, their expression can be energetically costly and must be tightly controlled to avoid fitness costs. Expression can be controlled at specific stages duri...
Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria [0.03%]
乳酸菌厌氧培养过程中的突变率和突变谱的偏向性
Owen F Hale,Michelle Yin,Megan G Behringer
Owen F Hale
The rate, spectrum, and biases of mutations represent a fundamental force shaping biological evolution. Convention often attributes oxidative DNA damage as a major driver of spontaneous mutations. Yet, despite the contribution of oxygen to ...
Human alphacoronavirus replication and innate immune induction in airway culture systems [0.03%]
人呼吸道上皮细胞体外模型中人α冠状病毒的复制及其诱导的天然免疫反应
Alejandra Fausto,Clayton J Otter,Leonel Torres et al.
Alejandra Fausto et al.
Compared with lethal betacoronaviruses, there is limited knowledge of how human alphacoronaviruses HCoV-NL63 (NL63) and HCoV-229E (229E) interact with host innate immune responses. We compared NL63 and 229E infections in human lung-derived ...
Antibody responses following COVID-19 vaccination and breakthrough infections in naïve and convalescent individuals suggest imprinting to the ancestral strain of SARS-CoV-2 [0.03%]
针对SARS-CoV-2祖先毒株的免疫印记导致疫苗接种及突破性感染后机体对新冠病毒的抗体反应受限
Siddhartha Mahanty,Emily M Eriksson,Peta Edler et al.
Siddhartha Mahanty et al.
The binding and neutralizing activity of SARS-CoV-2 antibodies are important correlates of protection of current COVID-19 vaccines. SARS-CoV-2 exposure status and COVID-19 vaccine types can influence these responses and the breadth of cross...
The pandemic gap of respiratory viruses during the COVID-19 pandemic [0.03%]
2019冠状病毒病大流行期间呼吸系统病毒的疫情差距
Viviana Simon,Daniel Floda,Charles Gleason et al.
Viviana Simon et al.
Respiratory viruses typically exhibit seasonal patterns, posing ongoing public health challenges. The coronavirus disease 2019 pandemic altered these patterns dramatically, with many common respiratory viruses disappearing from circulation ...
Clinical and environmental wastewater-based bacteriophage surveillance for high-impact diarrheal diseases, including cholera, in Bangladesh [0.03%]
孟加拉国临床上和环境中的废水噬菌体监测用于高影响性腹泻病（包括霍乱）的防控
Marjahan Akhtar,Md Ariful Amin,Subah Nuzhat Hussain et al.
Marjahan Akhtar et al.
Bacteriophages (phages) likely play a critical role in modulating transmission dynamics of diarrheal pathogens. This study investigated the role of phages in modulating the prevalence and seasonal patterns of major diarrheal pathogens, Vibr...
Microbial dispersal from surrounding vegetation influences phyllosphere microbiome assembly of corn and soybean [0.03%]
周边植被的微生物分散影响玉米和大豆叶片微生物组的构建
Kyle M Meyer,Steven E Lindow
Kyle M Meyer
Non-crop plants surrounding agricultural fields provide numerous ecological services to crops but have rarely been considered a source of microorganisms during the early stages of crop growth. In this study, we test whether crops in close p...
Population heterogeneity revealed in morphometric analysis of densely populated microbial swarm collectives [0.03%]
基于密集群体的形态学分析揭示微生物种群异质性
Eliotte E Garling,Shally Li,Kristin Ho et al.
Eliotte E Garling et al.
Uncovering cell morphology within communities is crucial to understanding how collective groups of organisms can function and adapt to their environments. Key questions remain regarding how cell morphology influences population behaviors an...
The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes [0.03%]
rmpADC的获得可使经典型肺炎克雷伯菌在缺乏其他高毒力相关基因的情况下增加毒力
Stephen M Salisbury,Taryn A Miner,Leslie A Kent et al.
Stephen M Salisbury et al.
Klebsiella pneumoniae is one of the most common causes of nosocomial infections, and the rise of drug-resistant K. pneumoniae strains is complicating treatment and contributing to a mounting global health crisis. K. pneumoniae has two patho...