Divergence in virus-host protein interactomes across species explains disparities in translational therapeutic success [0.03%]
跨物种病毒-宿主蛋白质相互作用组的分歧解释了翻译后治疗成功的差异
Kang Tang,Kai Zhuang,Zuyi Zhao et al.
Kang Tang et al.
Infectious viral diseases remain a major and persistent threat to human health, and findings from animal models often translate poorly to clinical applications. Here, we constructed protein interactomes for seven species, including humans, ...
Mechanisms by which proline reductase of Clostridioides difficile promotes efficient metabolism and disease progression in vivo [0.03%]
芽胞肉毒梭菌脯氨酸还原酶促进体内高效代谢和疾病进展的机制研究
Laura M Cersosimo,Madeline Graham,Auriane Monestier et al.
Laura M Cersosimo et al.
Clostridioides difficile is a toxin-producing pathogen that opportunistically infects those with a depleted gut microbiome, often triggered by antibiotic use. C. difficile preferentially utilizes Stickland amino acids, including proline, to...
Maternal vaccination protects dams and prevents in utero transmission of Rift Valley fever virus in rats [0.03%]
母体疫苗可防止小哺乳动物母体内 rift valley fever 病毒的垂直传播
Austin T Hertel,Cynthia M McMillen,Ryan M Hoehl et al.
Austin T Hertel et al.
In utero transmission and spontaneous fetal death are hallmarks of Rift Valley fever virus (RVFV) infection in pregnant animals. Compounding evidence indicates pregnant individuals are particularly vulnerable to RVFV, as in utero transmissi...
Functional dissection of Corynebacterium glutamicum Wag31 domains for septal recruitment and polar distribution during the cell cycle [0.03%]
芽孢杆菌谷氨酸棒杆菌Wag31域的功能解析及其在细胞周期中的隔膜募集和极性分布作用机制
Julienne Petit,Daniela Megrian,Mariano Martinez et al.
Julienne Petit et al.
Bacterial cell morphogenesis is controlled by the synthesis and organization of peptidoglycan and driven by multi-protein complexes, such as the divisome and elongasome. Here, we investigate the role of the Corynebacterium glutamicum DivIVA...
The co-localizing Zorya II, Druantia III, and ARMADA II defense systems on O-island 172 confer synergistic anti-phage defense in enterohemorrhagic Escherichia coli [0.03%]
O172菌毛岛II型佐里亚（Zorya）、德鲁安蒂亚（Druantia）和ARMADA II系统在肠出血性大肠杆菌中共同定位并发挥协同抗噬菌体作用
Huihui Li,Vu Van Loi,Costanza Borelli et al.
Huihui Li et al.
In this study, we found that the enterohemorrhagic Escherichia coli (EHEC) strain EDL933 Δstx1/2 is highly resistant to many phages. The three phage defense systems Zorya II, Druantia III, and DISARM-related Antiviral Defense Array (ARMADA...
A mechanosensitive ion channel is required for nematode predation in nematode-trapping fungi [0.03%]
捕食线虫真菌中机械敏感离子通道在控制线虫行为中的作用
Liao Zhang,Jieying Zhu,Jinyuan Kang et al.
Liao Zhang et al.
Mechanosensitive ion channels of small conductance-like channels (MSL) are conserved in cell-walled organisms and enable cellular responses to mechanical stimuli. Nematode-trapping fungi (NTF) rely on nematode-derived mechanical cues to for...
Emergence of an antigenically drifted and reassorted influenza B virus at the end of the 2024-25 influenza season [0.03%]
2024至2025年流感季节末期出现的一种抗原漂移和基因重排的乙型流感病毒
Elgin Akin,David A Villafuerte,Anne P Werner et al.
Elgin Akin et al.
Influenza B virus (IBV) is a significant contributor to annual and severe cases of influenza, particularly in the young and elderly. Late in the 2024-25 Northern Hemisphere influenza season, a surge of IBV cases was identified in the Johns ...
Webervirus phages exploit capsule- and O-antigen-targeting receptor-binding proteins to access diverse Klebsiella pneumoniae hosts [0.03%]
一种噬菌体利用荚膜和O抗原靶向黏附素蛋白来感染多种肺炎克雷伯氏菌宿主
Zixuan Ding,Yongqi Mu,Wenyue Sun et al.
Zixuan Ding et al.
Klebsiella pneumoniae frequently downregulates or completely loses its capsule. This abolishes infection by capsule-targeting phages but concomitantly may favor infection by phages that exploit non-capsular receptors. Although capsule-targe...
A phase-variable capsule facilitates Akkermansia muciniphila colonization of the intestinal mucus layer [0.03%]
一种可变的荚膜有利于Akkermansia muciniphila黏附到肠黏液层
Liam Gracia,Elizabeth R Hughes,Dustin R Middleton et al.
Liam Gracia et al.
Akkermansia muciniphila is a mucophilic commensal bacterium that significantly impacts metabolic and immune homeostasis. However, the bacterial factors involved in colonization of the gastrointestinal tract are not well understood. Here, we...
Alternative ribosomal protein RpmE2 is produced under zinc limitation in Neisseria gonorrhoeae and slows translation and bacterial growth [0.03%]
锌限制下果宁氏菌中可选核糖体蛋白RpmE2的生成及其对翻译和细菌生长的影响
Amy L Forehand,Kinga Malezyna,Keena S Thomas et al.
Amy L Forehand et al.
To enhance its pathogenic potential, Neisseria gonorrhoeae (Gc) pirates zinc from human metal sequestration proteins using TonB-dependent outer membrane transport systems. However, cytoplasmic mechanisms by which Gc adapts to zinc limitatio...