Elizabeth Vaisbourd,David Shaanan Glass,Yifan Yang et al.
Elizabeth Vaisbourd et al.
Subinhibitory antibiotic exposures are common in clinical and environmental contexts, yet their effects on bacterial growth dynamics remain incompletely understood. We studied the temporal response of Escherichia coli to a panel of bacteric...
The transferable resistome of biosolids-plasmid sequencing reveals carriage of clinically relevant antibiotic resistance genes [0.03%]
Kristin Hauschild,Masato Suzuki,Birgit Wolters et al.
Kristin Hauschild et al.
Biosolids, widely used as organic fertilizers due to their high nutrient content, are significant reservoirs for antimicrobial-resistant bacteria (ARB) carrying transferable antimicrobial resistance genes (ARGs). This study investigated the...
Samuel Lee,Matthew Radey,Pradeep Singh et al.
Samuel Lee et al.
Tandem gene duplications are spontaneous mutations that occur frequently but whose significance is often overlooked because they are genetically unstable and can be difficult to detect by sequencing. Here, we studied the spontaneous loss, a...
Candida albicans colonization modulates murine ethanol consumption and behavioral responses through elevation of serum prostaglandin E2 and impact on the striatal dopamine system [0.03%]
白色念珠菌定植通过提高血清前列腺素E2和影响黑质纹状体多巴胺能系统来调节小鼠的乙醇消耗和行为反应
Andrew W Day,Emma Hayes,Jeyra Perez-Lozada et al.
Andrew W Day et al.
Candida albicans is a commensal yeast that is a common component of the gastrointestinal (GI) microbiome of humans. C. albicans has been shown to bloom in the GI tract of individuals with alcohol use disorder (AUD) and can promote and incre...
Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes [0.03%]
金黄色葡萄球菌肺炎中α-毒素诱导的人单核细胞CX3CL1释放损害杀菌功能
Srikanth Mairpady Shambat,Puran Chen,Rocky M Barilla et al.
Srikanth Mairpady Shambat et al.
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin. In this study, w...
Could wastewater-based surveillance be key to combating antimicrobial resistance? [0.03%]
基于废水的监测可能是应对抗生素耐药性问题的关键吗？
José L Balcázar
José L Balcázar
Antimicrobial resistance (AMR) is one of the most urgent health threats of the 21st century. Surveillance is needed to enable timely interventions, close knowledge gaps, and anticipate long-term trends. Current frameworks rely heavily on cl...
Single-cell analysis of human airway epithelium identifies cell-type-specific responses to Aspergillus and Coccidioides [0.03%]
单细胞分析鉴别出人呼吸道上皮细胞对烟曲霉和头孢曲松的特异性反应类型
Alfred T Harding,Arianne J Crossen,Yanting Zhang et al.
Alfred T Harding et al.
Respiratory fungal infections pose a significant threat to human health. Animal models do not fully recapitulate human disease, necessitating advanced models to study human-fungal pathogen interactions. In this study, we utilized primary hu...
Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella ki ngae [0.03%]
黏附、运动和遗传物质摄取的调节因子协调未成年人Kingella kingae IV型菌毛组装
Taylor A Yount,Eric A Porsch,Joseph W St Geme rd
Taylor A Yount
Type IV pili (T4P) are dynamic surface appendages that mediate adherence, motility, and DNA uptake in Kingella kingae, an important pediatric pathogen that causes osteoarticular infections, bacteremia, and endocarditis. While the major pili...
Cell wall mechanical stress could coordinate septal synthesis and scission in Staphylococcus aureus [0.03%]
金黄色葡萄球菌中细胞壁机械应力可以协调隔膜合成和分裂
Sheila Hoshyaripour,Marco Mauri,Jamie K Hobbs et al.
Sheila Hoshyaripour et al.
Staphylococcus aureus divides by building a septum and then splitting into two daughter cells. Scission should be coordinated with septum completion to avoid cell lysis; however, it is not known how this is achieved, or what the relative ro...
Reconsidering the Toxoplasma gondii interactome: opportunities beyond crosslinking mass spectrometry [0.03%]
reconsidering toxoplasma gondii互作组蛋白鸟氨酸脱羧酶：质谱联用技术之外的机会
Nathkapach K Rattanapitoon,Patpicha Arunsan,Nav La et al.
Nathkapach K Rattanapitoon et al.