Japanese encephalitis virus NS1 and NS4B synergistically target TLR3 signaling to promote viral replication [0.03%]
Quan Zeng,Maozhou He,Mengyao Li et al.
Quan Zeng et al.
To establish effective infection, viral pathogens employ diverse strategies through encoded proteins to interfere with host antiviral responses. While previous studies have predominantly focused on elucidating the mechanisms by which indivi...
Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis [0.03%]
Joseph F Carr,Carolina Basurto De Santiago,Shivani A Bhut et al.
Joseph F Carr et al.
In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane protei...
12-Lipoxygenase (12-LOX) plays a key role in the hyperinflammatory response caused by SARS-CoV-2 [0.03%]
Melinee D&#x;silva,Karen Jackson,Matthew T Vaughan et al.
Melinee D&#x;silva et al.
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant global morbidity and mortality. The severe disease outcomes are often associated with a hyperinflammatory response known as a "cytokine storm." The mechanisms und...
Cross-utilization of viral polymerase: parainfluenza virus hijacks the RdRp of porcine sapelovirus to facilitate its replication during co-infection [0.03%]
Jianing Chen,Shengyu Lin,Jiao Tang et al.
Jianing Chen et al.
Parainfluenza virus is a significant respiratory pathogen affecting both humans and animals, capable of causing acute respiratory tract infections in infants and immunocompromised individuals. Recently, parainfluenza virus 5 (PIV5) has been...
Kristen Ramsey,Shoichi Tachiyama,Apolline Brossard et al.
Kristen Ramsey et al.
Many Gram-negative pathogens, including Pseudomonas aeruginosa, use a type III secretion system (T3SS) to intoxicate eukaryotic cells. The T3SS is an important virulence factor linked to increased morbidity and mortality in infections, yet ...
Sage J B Dunham,Gregory A Willkeen,Ben Darby et al.
Sage J B Dunham et al.
Ecological guilds are groups of organisms that utilize the same class of resources and occupy similar niches, regardless of their taxonomic identities. Here we propose the Guild Model for Cystic Fibrosis Airway Microbial Ecology, which cons...
Mice on a high-fat diet have reduced immunopathology and an altered immune response during respiratory syncytial virus infection [0.03%]
Kendall T Whitt,Dorothea R Morris,Pamela H Brigleb et al.
Kendall T Whitt et al.
Obesity has been identified as an independent risk factor for increased morbidity and mortality during pandemic H1N1 influenza and SARS-CoV-2 infections. Various studies have determined that obese hosts have dysregulated antiviral responses...
Brian Chung,Shi Wang,Zhao Hao et al.
Brian Chung et al.
Drought has consequences for microbial decomposition rates, including indirect effects through changes in plant litter chemistry. Here, we studied the impact of a decade-long drought on plant litter chemistry and microbial decomposition tra...
Vancomycin disrupts mitochondrial morphology and function and impairs macrophage fungal killing [0.03%]
Ebrima Bojang,Lozan Sheriff,Emma Morris et al.
Ebrima Bojang et al.
Vancomycin is a widely prescribed antibiotic used in the treatment of gram-positive bacterial infections. We previously showed that this antibiotic disrupted protective antifungal immune responses via microbiome dysbiosis, enhancing suscept...
I S R Storer,B P Thornton,A S Hackett et al.
I S R Storer et al.
Invasive infections caused by Aspergillus fumigatus have high mortality rates, even when treated with the first-line agent voriconazole. The global emergence of azole resistance further increases treatment failure, underscoring the urgent n...