The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe [0.03%]
假单胞菌_PUTIDA_KT2440_的争议身份：当分类学家重新命名你最喜爱的微生物时
Victor de Lorenzo,Danilo Pérez-Pantoja,Juan Luis Ramos et al.
Victor de Lorenzo et al.
Pseudomonas putida KT2440 has long served as a reference strain in environmental microbiology, biotechnology, and synthetic biology. Its recent taxonomic reclassification as P. alloputida, however, exemplifies the tensions generated by top-...
Tracing the origin and evolution of specialized biosynthetic pathways in marine organisms [0.03%]
探究海洋生物特化生物合成途径的起源和演化
Laure Martinelli,Nicolas Papon,Olivier P Thomas et al.
Laure Martinelli et al.
Harmful algal blooms (HABs) pose public health and ecological risks in aquatic environments. HABs drive the bioaccumulation of a specific family of specialized metabolites known as "kainoids." Kainoid derivatives, such as kainic acid (KA) a...
YhcB mediates growth-phase control of fatty acid biosynthesis through regulation of acetyl-CoA carboxylase [0.03%]
YhcB通过调节乙酰辅酶A羧化酶介导脂肪酸生物合成的生长阶段控制
Hannah M Stanley,M Stephen Trent
Hannah M Stanley
Cell envelope biogenesis is an essential process that requires coordination of many complex pathways, including the synthesis of fatty acids, lipopolysaccharides, and glycerophospholipids. Loss of Escherichia coli YhcB has been demonstrated...
Intestinal epithelial Tet2 deficiency reprograms the gut microbiota through bile acid metabolic alterations [0.03%]
肠上皮Tet2缺乏通过胆汁酸代谢重编程肠道微生物群
Nan Wang,Qing Liu,Fengjiao Huo et al.
Nan Wang et al.
Epigenetic mechanisms are increasingly recognized as critical regulators of host-microbiota interactions, yet their specific roles in gut homeostasis remain elusive. Here, we demonstrate that intestinal epithelial-specific deletion of the D...
Mechanistic insights into SteAB regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis [0.03%]
关于结核分枝杆菌中SteAB调控细胞壁水解酶RipA的机制研究
Giacomo Carloni,Quentin Gaday,Daniela Megrian et al.
Giacomo Carloni et al.
D,L-endopeptidase RipA is the major peptidoglycan (PG) hydrolase required for cell separation in Mycobacterium tuberculosis (Mtb), as RipA defects severely hinder cell division and increase antibiotic vulnerability. Despite extensive studie...
The Dp16 Down syndrome mouse model does not exhibit oral interferon-gammopathy or susceptibility to oral candidiasis [0.03%]
DP16唐氏综合症小鼠模型没有口腔干扰素-γ病或口腔念珠菌感染易感性
Ashira Lubkin,Ramon A Lujan,Sergio M Pontejo et al.
Ashira Lubkin et al.
Down syndrome, or Trisomy 21, is associated with excessive interferon (IFN) signaling and concomitant susceptibility to both autoimmunity and immunodeficiency. One of the many clinical phenotypes observed in people with Down syndrome is inc...
Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication [0.03%]
核衣壳蛋白捕获DDX5和RNMT促进冠状病毒复制中的病毒RNA合成及病毒蛋白翻译
Yuchang Liu,Ning Kong,Xinyu Yang et al.
Yuchang Liu et al.
Coronaviruses (CoVs) hijack host RNA-binding proteins (RBPs) to facilitate their replication, but the viral proteins and host RBDs that participate in the synthesis of viral RNA and protein are unclear. In this study, we revealed that DEAD-...
The adenovirus oncoprotein E1B-55K reshapes epigenetic histone modifications in primary human cells [0.03%]
腺病毒致癌蛋白E1B-55K重塑原代人类细胞表观遗传修饰
Konstantin von Stromberg,Laura Seddar,Britta Gornott et al.
Konstantin von Stromberg et al.
Oncogenic viruses can induce epigenetic changes in host cells, which may contribute to cell transformation and tumorigenesis by altering gene expression patterns. Human adenoviruses, while primarily known for their lytic infections, have al...
Confidence-based prediction of antibiotic resistance at the patient level [0.03%]
基于信心的抗生素抗性患者水平预测方法
Juan S Inda-Díaz,Anna Johnning,Magnus Hessel et al.
Juan S Inda-Díaz et al.
Rapid and accurate diagnostics of bacterial infections are necessary for efficient treatment of antibiotic-resistant pathogens. Cultivation-based methods, such as antibiotic susceptibility testing (AST), are limited by bacterial growth rate...
Captivity drives multi-generational shifts in the gut microbiome that mirror changing animal fitness [0.03%]
圈养可导致肠道微生物组跨世代变化，并且这些变化与动物体形的改变相一致
Candace L Williams,Claire E Williams,Shauna N D King et al.
Candace L Williams et al.
Gut microbiomes can dramatically affect host health and fitness, but can shift rapidly under changing environmental conditions. Understanding the interplay between microbiota, environmental pressures, and host responses is critical for pred...