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Angewandte Chemie (International ed. in English). 2018 Feb 23;57(9):2441-2444. doi: 10.1002/anie.201711390 Q116.92025

Synthesis of α-Chiral Ketones and Chiral Alkanes Using Radical Polar Crossover Reactions of Vinyl Boron Ate Complexes

利用乙烯基硼配合物的极性交叉自由基反应合成α-手性酮和光学活性烷烃 翻译改进

Carolin Gerleve  1, Marvin Kischkewitz  1, Armido Studer  1

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  • 1 Westfälische Wilhelms-Universität, Organisch-Chemisches Institut, Corrensstrasse 40, 48149, Münster, Germany.
  • DOI: 10.1002/anie.201711390 PMID: 29239507

    摘要 Ai翻译

    Vinyl boron ate complexes of enantioenriched secondary alkyl pinacolboronic esters undergo stereospecific radical-induced 1,2-migration in radical polar crossover reactions. In this three-component process various commercially available alkyl iodides act as radical precursors and light is used for chain initiation. Subsequent oxidation and protodeborylation leads to valuable α-chiral ketones and chiral alkanes, respectively, with excellent enantiopurity.

    Keywords: boronic esters; protodeborylation; radical polar crossover reactions; α-chiral ketones.

    Keywords:chiral ketones; chiral alkanes; vinyl boron ate complexes

    Copyright © Angewandte Chemie (International ed. in English). 中文内容为AI机器翻译,仅供参考!

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    期刊名:Angewandte chemie-international edition

    缩写:ANGEW CHEM INT EDIT

    ISSN:N/A

    e-ISSN:1521-3773

    IF/分区:16.9/Q1

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    Synthesis of α-Chiral Ketones and Chiral Alkanes Using Radical Polar Crossover Reactions of Vinyl Boron Ate Complexes